Solid-Phase Synthesis of PROTACs and SNIPERs on Backbone Amide Linked (BAL) Resin

Liam Thomas Hales, Philip Evan Thompson

Research output: Contribution to journalArticleResearchpeer-review


Developing straightforward but flexible approaches to PROTAC synthesis that can incorporate the structural elements of emerging designs can improve the quality and efficiency of PROTAC development. Solid-phase approaches could offer many advantages over conventional PROTAC synthesis if diverse chemistries and topographies can be incorporated. We have exploited the backbone-amide-linked (BAL) resin to employ an array of solid-phase organic reactions, providing access to VHL- and IAP-targeting degraders using the BRD4-targeting JQ1 conjugates as examples.

Original languageEnglish
Article numbere202301975
Number of pages10
JournalChemistry - A European Journal
Issue number56
Publication statusPublished - 9 Oct 2023


  • BAL resin
  • solid phase synthesis

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