Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy

Cameron C. Hanna; Sameer S. Kulkarni; Emma E. Watson; Bhavesh Premdjee; Richard J. Payne

doi:10.1039/c7cc00823f

Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy

Cameron C. Hanna, Sameer S. Kulkarni, Emma E. Watson, Bhavesh Premdjee, Richard J. Payne

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.

Original language	English
Pages (from-to)	5424-5427
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	39
DOIs	https://doi.org/10.1039/c7cc00823f
Publication status	Published - 17 May 2017
Externally published	Yes

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title = "Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy",

abstract = "Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.",

author = "Hanna, \{Cameron C.\} and Kulkarni, \{Sameer S.\} and Watson, \{Emma E.\} and Bhavesh Premdjee and Payne, \{Richard J.\}",

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year = "2017",

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AU - Hanna, Cameron C.

AU - Kulkarni, Sameer S.

AU - Watson, Emma E.

AU - Premdjee, Bhavesh

AU - Payne, Richard J.

PY - 2017/5/17

Y1 - 2017/5/17

N2 - Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.

AB - Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.

UR - https://www.scopus.com/pages/publications/85021672006

U2 - 10.1039/c7cc00823f

DO - 10.1039/c7cc00823f

M3 - Article

C2 - 28462972

AN - SCOPUS:85021672006

SN - 1359-7345

VL - 53

SP - 5424

EP - 5427

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy

Abstract

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