TY - JOUR
T1 - Solid phase synthesis of C-terminal peptide amides
T2 - Development of a new aminoethyl-polystyrene linker on the Multipin(TM) solid support
AU - Bui, Chinh T.
AU - Bray, Andrew M.
AU - Nguyen, Thao
AU - Ercole, Francis
AU - Maeji, N. Joe
PY - 2000/5
Y1 - 2000/5
N2 - A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(c) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H2O). Model peptide amides and other N-alkylated peptide amides have been successfully synthesized in good yield and purity. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.
AB - A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(c) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H2O). Model peptide amides and other N-alkylated peptide amides have been successfully synthesized in good yield and purity. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.
KW - Acetophenone-based linker
KW - Aminoethyl-polystyrene
KW - Multipin solid support
KW - Solid-phase synthesis of peptide amide
UR - http://www.scopus.com/inward/record.url?scp=0034021915&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1387(200005)6:5<243::AID-PSC251>3.0.CO;2-4
DO - 10.1002/(SICI)1099-1387(200005)6:5<243::AID-PSC251>3.0.CO;2-4
M3 - Article
C2 - 10823493
AN - SCOPUS:0034021915
SN - 1075-2617
VL - 6
SP - 243
EP - 250
JO - Journal of Peptide Science
JF - Journal of Peptide Science
IS - 5
ER -