Solid phase synthesis of C-terminal peptide amides: Development of a new aminoethyl-polystyrene linker on the Multipin(TM) solid support

Chinh T. Bui, Andrew M. Bray, Thao Nguyen, Francis Ercole, N. Joe Maeji

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2 Citations (Scopus)


A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(c) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H2O). Model peptide amides and other N-alkylated peptide amides have been successfully synthesized in good yield and purity. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalJournal of Peptide Science
Issue number5
Publication statusPublished - May 2000
Externally publishedYes


  • Acetophenone-based linker
  • Aminoethyl-polystyrene
  • Multipin solid support
  • Solid-phase synthesis of peptide amide

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