A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(c) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H2O). Model peptide amides and other N-alkylated peptide amides have been successfully synthesized in good yield and purity. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.
|Number of pages||8|
|Journal||Journal of Peptide Science|
|Publication status||Published - May 2000|
- Acetophenone-based linker
- Multipin solid support
- Solid-phase synthesis of peptide amide