Solid phase microextraction for quantitative analysis – Expectations beyond design?

Yada Nolvachai, Michelle S.S. Amaral, Riley Herron, Philip J. Marriott

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


Solid phase microextraction (SPME) is a convenient, effective and green sample preparation technique, offering excellent compatibility with different chromatography methods. This review presents an overview of the history of the SPME technique and its early adaptation based on reported patents, followed by some current SPME designs, and intended usage, especially for gas chromatography (GC) applications. Particular focus on quantification approaches in SPME is included, with emphases on the methodology chosen for implementation, correct performance of quantification and validation, and the calibration method. The article concludes by highlighting some innovative SPME-related techniques, some of which are chosen for their quantitative coverage of analytes and their reported applications.

Original languageEnglish
Article number100048
Number of pages15
JournalGreen Analytical Chemistry
Publication statusPublished - Mar 2023


  • Needle trap
  • Quantitative SPME
  • Solid phase microextraction
  • SPME Arrow
  • SPME patent
  • SPME technology

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