Drug repurpose or reposition has recently been recognized as a high-performance strategy for developing therapeutic agents for cancer treatment. This approach can significantly reduce the risk of failure, shorten R&D time, and minimize cost and regulatory obstacles. On the other hand, nanotechnology-based delivery systems have been extensively investigated in cancer therapy due to their remarkable ability to overcome drug delivery challenges, enhance tumor specific targeting, and reduce toxic side effects. With increasing knowledge accumulated over the past decades, nanoparticle formulation and delivery have opened up a new avenue for repurposing drugs and demonstrated promising results in advanced cancer therapy. In this review, we summarize recent development of nano-delivery and formulation systems based on soft (i.e. DNA nanocages, nanogels and dendrimers) and condensed (i.e. noble metal nanoparticles and metal-organic frameworks) nanomaterials, as well as their theranostic applications in drug repurpose against cancer.
Yang, W., Veroniaina, H., Qi, X., Chen , P., Li, F., & Ke , P. C. (Accepted/In press). Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose. Advanced Therapeutics. https://doi.org/10.1002/adtp.201900102