Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis

Giovanni Fiorito, Cathal McCrory, Oliver Robinson, Cristian Carmeli, Carolina Ochoa Rosales, Yan Zhang, Elena Colicino, Pierre Antoine Dugué, Fanny Artaud, Gareth J. McKay, Ayoung Jeong, Pashupati P. Mishra, Therese H. Nøst, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Giuseppe Matullo, Simonetta GuarreraMartina Gandini, Murielle Bochud, Emmanouil Dermitzakis, Taulant Muka, Joel Schwartz, Pantel S. Vokonas, Allan Just, Allison M. Hodge, Graham G. Giles, Melissa C. Southey, Mikko A. Hurme, Ian Young, Amy Jayne McKnight, Sonja Kunze, Melanie Waldenberger, Annette Peters, Lars Schwettmann, Eiliv Lund, Andrea Baccarelli, Roger L. Milne, Rose A. Kenny, Alexis Elbaz, Hermann Brenner, Frank Kee, Trudy Voortman, Nicole Probst-Hensch, Terho Lehtimäki, Paul Elliot, Silvia Stringhini, Paolo Vineis, Silvia Polidoro, the BIOS Consortium, the LIFEPATH consortium

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect. Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.

Original languageEnglish
Pages (from-to)2045-2070
Number of pages26
JournalAging
Volume11
Issue number7
DOIs
Publication statusPublished - 15 Apr 2019

Keywords

  • Biological aging
  • Education
  • Epigenetic clocks
  • Socioeconomic position

Cite this

Fiorito, G., McCrory, C., Robinson, O., Carmeli, C., Rosales, C. O., Zhang, Y., ... the LIFEPATH consortium (2019). Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis. Aging, 11(7), 2045-2070. https://doi.org/10.18632/aging.101900