TY - JOUR
T1 - Social adversity and epigenetic aging
T2 - A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation
AU - Fiorito, Giovanni
AU - Polidoro, Silvia
AU - Dugué, Pierre Antoine
AU - Kivimaki, Mika
AU - Ponzi, Erica
AU - Matullo, Giuseppe
AU - Guarrera, Simonetta
AU - Assumma, Manuela B.
AU - Georgiadis, Panagiotis
AU - Kyrtopoulos, Soterios A.
AU - Krogh, Vittorio
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Chadeau-Hyam, Marc
AU - Stringhini, Silvia
AU - Severi, Gianluca
AU - Hodge, Allison M.
AU - Giles, Graham G.
AU - Marioni, Riccardo
AU - Karlsson Linnér, Richard
AU - O'Halloran, Aisling M.
AU - Kenny, Rose A.
AU - Layte, Richard
AU - Baglietto, Laura
AU - Robinson, Oliver
AU - McCrory, Cathal
AU - Milne, Roger L.
AU - Vineis, Paolo
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
AB - Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
UR - http://www.scopus.com/inward/record.url?scp=85035225913&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-16391-5
DO - 10.1038/s41598-017-16391-5
M3 - Article
AN - SCOPUS:85035225913
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 16266
ER -
