SNP genotyping defines complex gene-flow boundaries among african malaria vector mosquitoes

D. E. Neafsey, M. K.N. Lawniczak, D. J. Park, S. N. Redmond, M. B. Coulibaly, S. F. Traoré, N. Sagnon, C. Costantini, C. Johnson, R. C. Wiegand, F. H. Collins, E. S. Lander, D. F. Wirth, F. C. Kafatos, N. J. Besansky, G. K. Christophides, M. A.T. Muskavitch

Research output: Contribution to journalArticleResearchpeer-review

121 Citations (Scopus)

Abstract

Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.

Original languageEnglish
Pages (from-to)514-517
Number of pages4
JournalScience
Volume330
Issue number6003
DOIs
Publication statusPublished - 22 Oct 2010
Externally publishedYes

Keywords

  • *Gene Flow
  • *Genes
  • Animals
  • Anopheles gambiae
  • Anopheles gambiae/*genetics
  • Anopheles gambiae: genetics
  • Female
  • Gene Flow
  • Genes
  • Genotype
  • Insect
  • Insect Vectors
  • Insect Vectors/*genetics
  • Insect Vectors: genetics
  • Malaria
  • Polymorphism
  • Single Nucleotide
  • Single Nucleotide/*genetics
  • Single Nucleotide: genetics

Cite this