TY - JOUR
T1 - Smart pH-Sensitive Nanogels for Controlled Release in an Acidic Environment
AU - Wei, Peng
AU - Gangapurwala, Gauri
AU - Pretzel, David
AU - Leiske, Meike N.
AU - Wang, Limin
AU - Hoeppener, Stephanie
AU - Schubert, Stephanie
AU - Brendel, Johannes C.
AU - Schubert, Ulrich S.
PY - 2019
Y1 - 2019
N2 - The encapsulation of therapeutic compounds into nanosized delivery vectors has become an important strategy to improve efficiency and reduce side effects in drug delivery applications. Here, we report the synthesis of pH-sensitive nanogels, which are based on the monomer N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide (DMDOMA) bearing an acid cleavable acetal group. Degradation studies revealed that these nanogels hydrolyze under acidic conditions and degrade completely, depending on the cross-linker, but are stable in physiological environment. The best performing system was further studied regarding its release kinetics using the anticancer drug doxorubicin. In vitro studies revealed a good compatibility of the unloaded nanogel and the capability of the doxorubicin loaded nanogel to mediate cytotoxic effects in a concentration and time-dependent manner with an even higher efficiency than the free drug. Based on the investigated features, the presented nanogels represent a promising and conveniently prepared alternative to existing carrier systems for drug delivery.
AB - The encapsulation of therapeutic compounds into nanosized delivery vectors has become an important strategy to improve efficiency and reduce side effects in drug delivery applications. Here, we report the synthesis of pH-sensitive nanogels, which are based on the monomer N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide (DMDOMA) bearing an acid cleavable acetal group. Degradation studies revealed that these nanogels hydrolyze under acidic conditions and degrade completely, depending on the cross-linker, but are stable in physiological environment. The best performing system was further studied regarding its release kinetics using the anticancer drug doxorubicin. In vitro studies revealed a good compatibility of the unloaded nanogel and the capability of the doxorubicin loaded nanogel to mediate cytotoxic effects in a concentration and time-dependent manner with an even higher efficiency than the free drug. Based on the investigated features, the presented nanogels represent a promising and conveniently prepared alternative to existing carrier systems for drug delivery.
UR - http://www.scopus.com/inward/record.url?scp=85056571781&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.8b01228
DO - 10.1021/acs.biomac.8b01228
M3 - Article
AN - SCOPUS:85056571781
SN - 1525-7797
VL - 20
SP - 130
EP - 140
JO - Biomacromolecules
JF - Biomacromolecules
IS - 1
ER -