Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Sook Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E. Lang, Keith R. Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A. Baugh, Anup K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Charalambos C. Charalambous, Valentina Ciullo, Adriana B. ConfortoRichard C. Craddock, Adrienne N. Dula, Natalia Egorova, Wuwei Feng, Kelene A. Fercho, Chris M. Gregory, Colleen A. Hanlon, Kathryn S. Hayward, Jess A. Holguin, Brenton Hordacre, Darryl H. Hwang, Steven A. Kautz, Mohamed Salah Khlif, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Bethany Lo, Jingchun Liu, David Lin, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Jan Egil Nordvik, Matthew A. Petoe, Fabrizio Piras, Sharmila Raju, Ander Ramos-Murguialday, Kate P. Revill, Pamela Roberts, Andrew D. Robertson, Heidi M. Schambra, Na Jin Seo, Mark S. Shiroish, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong Tang, Gregory T. Thielman, Vincent N. Thijs, Daniela Vecchio, Nick S. Ward, Lars T. Westlye, Carolee J. Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven L. Wolf, Steven C. Cramer, Paul M. Thompson, on behalf of the ENIGMA Stroke Recovery Working Group

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3 Citations (Scopus)

Abstract

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P<0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. Worse sensorimotor behaviour was associated with a smaller ipsilesional thalamic volume in both early (n=179; d=0.68) and subacute (n=274, d=0.46) stroke. In chronic stroke (n=404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d=0.52) and nucleus accumbens (d=0.39) volumes, and a larger ipsilesional lateral ventricle (d=-0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n=256) was associated with smaller ipsilesional putamen (d=0.72) and larger lateral ventricle (d=-0.41) volumes, while several measures of activity limitations (n=116) showed no significant relationships. In the full cohort across all time (n=828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d=0.23), putamen (d=0.33), thalamus (d=0.33) and lateral ventricle (d=0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes.

Original languageEnglish
Article numberfcab254
Number of pages15
JournalBrain Communications
Volume3
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • MRI
  • rehabilitation
  • sensorimotor behaviour
  • stroke
  • subcortical volumes

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