Small Deep Cerebral Infarcts Associated With Occlusive Internal Carotid Artery Disease

A Hemodynamic Phenomenon?

John A. Waterston, Martin M. Brown, Paul Butler, Michael Swash

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

Abstract

Small deep cerebral infarcts, often referred to as lacunes, have been traditionally associated with small-vessel disease affecting the deep penetrating arterial system. We describe 10 cases where these infarcts were associated with severe, ipsilateral internal carotid artery occlusive disease. Seven of these patients also had severe occlusive disease of the contralateral internal carotid artery. The clinical and radiologic features, in combination with studies of cerebral blood flow, were consistent with hemodynamically mediated cerebral ischemia. Occlusive internal carotid artery disease may be more commonly associated with hemodynamic cerebral ischemia than previously believed, and small cerebral infarcts in the deep arterial border zone areas are likely to be an important manifestation of this process.

Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalArchives of Neurology
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Cite this

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title = "Small Deep Cerebral Infarcts Associated With Occlusive Internal Carotid Artery Disease: A Hemodynamic Phenomenon?",
abstract = "Small deep cerebral infarcts, often referred to as lacunes, have been traditionally associated with small-vessel disease affecting the deep penetrating arterial system. We describe 10 cases where these infarcts were associated with severe, ipsilateral internal carotid artery occlusive disease. Seven of these patients also had severe occlusive disease of the contralateral internal carotid artery. The clinical and radiologic features, in combination with studies of cerebral blood flow, were consistent with hemodynamically mediated cerebral ischemia. Occlusive internal carotid artery disease may be more commonly associated with hemodynamic cerebral ischemia than previously believed, and small cerebral infarcts in the deep arterial border zone areas are likely to be an important manifestation of this process.",
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Small Deep Cerebral Infarcts Associated With Occlusive Internal Carotid Artery Disease : A Hemodynamic Phenomenon? / Waterston, John A.; Brown, Martin M.; Butler, Paul; Swash, Michael.

In: Archives of Neurology, Vol. 47, No. 9, 01.01.1990, p. 953-957.

Research output: Contribution to journalArticleResearchpeer-review

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