Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 140 - 149 |
| Number of pages | 10 |
| Journal | FEMS Microbiology Letters |
| Volume | 352 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Small animal models for the study of Clostridium difficile disease pathogenesis. / Hutton, Melanie Lisa; Mackin, Kate Elizabeth; Chakravorty, Anjana; Lyras, Dena.
In: FEMS Microbiology Letters, Vol. 352, No. 2, 2014, p. 140 - 149.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Small animal models for the study of Clostridium difficile disease pathogenesis
AU - Hutton, Melanie Lisa
AU - Mackin, Kate Elizabeth
AU - Chakravorty, Anjana
AU - Lyras, Dena
PY - 2014
Y1 - 2014
N2 - Clostridium difficile is the leading cause of bacterial antibiotic-associated diarrhoea in hospitals in the developed world. Despite this notoriety, the complex mechanisms employed by this pathogen to overcome innate host defences and induce fulminant disease are poorly understood. Various animal models have been used extensively for C. difficile research to study disease pathogenesis. Until recently, the most commonly used C. difficile disease model has utilised hamsters; however, mouse and pig models have now been developed that unravel different aspects of C. difficile pathology. This review summarises key aspects of the small animal models currently used in C. difficile studies with a specific focus on major differences between them. Furthermore, this review highlights the advantages and disadvantages of each model and illustrates that careful consideration is required when selecting models for use in C. difficile research.
AB - Clostridium difficile is the leading cause of bacterial antibiotic-associated diarrhoea in hospitals in the developed world. Despite this notoriety, the complex mechanisms employed by this pathogen to overcome innate host defences and induce fulminant disease are poorly understood. Various animal models have been used extensively for C. difficile research to study disease pathogenesis. Until recently, the most commonly used C. difficile disease model has utilised hamsters; however, mouse and pig models have now been developed that unravel different aspects of C. difficile pathology. This review summarises key aspects of the small animal models currently used in C. difficile studies with a specific focus on major differences between them. Furthermore, this review highlights the advantages and disadvantages of each model and illustrates that careful consideration is required when selecting models for use in C. difficile research.
UR - http://femsle.oxfordjournals.org/content/352/2/140.full-text.pdf
U2 - 10.1111/1574-6968.12367
DO - 10.1111/1574-6968.12367
M3 - Article
VL - 352
SP - 140
EP - 149
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
SN - 0378-1097
IS - 2
ER -