Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu; S. Sidhu; Greg Falzon; S. Nazaretian; S. A. Hart; J. G. Fox; R. A. Lewis

doi:10.1007/978-3-642-03879-2-170

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu
, S. Sidhu
, Greg Falzon
, S. Nazaretian
, S. A. Hart
, J. G. Fox
, R. A. Lewis

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

1 Citation (Scopus)

Abstract

Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
Pages	607-610
Number of pages	4
Volume	25
Edition	2
DOIs	https://doi.org/10.1007/978-3-642-03879-2-170
Publication status	Published - 2009
Event	World Congress on Medical Physics and Biomedical Engineering 2009 - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Conference

Conference	World Congress on Medical Physics and Biomedical Engineering 2009
Abbreviated title	WC 2009
Country/Territory	Germany
City	Munich
Period	7/09/09 → 12/09/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Extra-cellular matrix
X-ray scattering

Access to Document

10.1007/978-3-642-03879-2-170

Cite this

Siu, K. K. W., Sidhu, S., Falzon, G., Nazaretian, S., Hart, S. A., Fox, J. G., & Lewis, R. A. (2009). Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging (2 ed., Vol. 25, pp. 607-610) https://doi.org/10.1007/978-3-642-03879-2-170

@inproceedings{91f91765e756423288f5f0a868f9b29e,

title = "Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources",

abstract = "Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.",

keywords = "Breast cancer, Extra-cellular matrix, X-ray scattering",

author = "Siu, \{K. K.W.\} and S. Sidhu and Greg Falzon and S. Nazaretian and Hart, \{S. A.\} and Fox, \{J. G.\} and Lewis, \{R. A.\}",

year = "2009",

doi = "10.1007/978-3-642-03879-2-170",

language = "English",

isbn = "9783642038785",

volume = "25",

pages = "607--610",

booktitle = "World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging",

edition = "2",

note = "World Congress on Medical Physics and Biomedical Engineering 2009, WC 2009 ; Conference date: 07-09-2009 Through 12-09-2009",

}

Siu, KKW, Sidhu, S, Falzon, G, Nazaretian, S, Hart, SA, Fox, JG & Lewis, RA 2009, Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. in World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. 2 edn, vol. 25, pp. 607-610, World Congress on Medical Physics and Biomedical Engineering 2009, Munich, Bavaria, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03879-2-170

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. / Siu, K. K.W.; Sidhu, S.; Falzon, Greg et al.
World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. Vol. 25 2. ed. 2009. p. 607-610.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Small angle X-ray scattering signatures for breast cancer detection

T2 - World Congress on Medical Physics and Biomedical Engineering 2009

AU - Siu, K. K.W.

AU - Sidhu, S.

AU - Falzon, Greg

AU - Nazaretian, S.

AU - Hart, S. A.

AU - Fox, J. G.

AU - Lewis, R. A.

PY - 2009

Y1 - 2009

N2 - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

AB - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

KW - Breast cancer

KW - Extra-cellular matrix

KW - X-ray scattering

UR - https://www.scopus.com/pages/publications/77950897680

U2 - 10.1007/978-3-642-03879-2-170

DO - 10.1007/978-3-642-03879-2-170

M3 - Conference Paper

AN - SCOPUS:77950897680

SN - 9783642038785

VL - 25

SP - 607

EP - 610

BT - World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging

Y2 - 7 September 2009 through 12 September 2009

ER -

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

Abstract

Conference

UN SDGs

Keywords

Access to Document

Other files and links

Cite this