Small angle X-ray scattering signatures for breast cancer detection

Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu, S. Sidhu, Greg Falzon, S. Nazaretian, S. A. Hart, J. G. Fox, R. A. Lewis

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
Pages607-610
Number of pages4
Volume25
Edition2
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering 2009: Diagnostic Imaging - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering 2009
Abbreviated titleWC 2009
CountryGermany
CityMunich
Period7/09/0912/09/09

Keywords

  • Breast cancer
  • Extra-cellular matrix
  • X-ray scattering

Cite this

Siu, K. K. W., Sidhu, S., Falzon, G., Nazaretian, S., Hart, S. A., Fox, J. G., & Lewis, R. A. (2009). Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging (2 ed., Vol. 25, pp. 607-610) https://doi.org/10.1007/978-3-642-03879-2-170
Siu, K. K.W. ; Sidhu, S. ; Falzon, Greg ; Nazaretian, S. ; Hart, S. A. ; Fox, J. G. ; Lewis, R. A. / Small angle X-ray scattering signatures for breast cancer detection : Direct comparison of synchrotron and laboratory x-ray sources. World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. Vol. 25 2. ed. 2009. pp. 607-610
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abstract = "Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.",
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Siu, KKW, Sidhu, S, Falzon, G, Nazaretian, S, Hart, SA, Fox, JG & Lewis, RA 2009, Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. in World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. 2 edn, vol. 25, pp. 607-610, World Congress on Medical Physics and Biomedical Engineering 2009, Munich, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03879-2-170

Small angle X-ray scattering signatures for breast cancer detection : Direct comparison of synchrotron and laboratory x-ray sources. / Siu, K. K.W.; Sidhu, S.; Falzon, Greg; Nazaretian, S.; Hart, S. A.; Fox, J. G.; Lewis, R. A.

World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. Vol. 25 2. ed. 2009. p. 607-610.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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Siu KKW, Sidhu S, Falzon G, Nazaretian S, Hart SA, Fox JG et al. Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. 2 ed. Vol. 25. 2009. p. 607-610 https://doi.org/10.1007/978-3-642-03879-2-170