Slowing the progression of adult renal

Merlin C. Thomas, Timothy H. Mathew

Research output: Contribution to journalReview ArticleResearchpeer-review


End-stage renal disease (ESRD) is the term used to describe the concluding stages of kidney failure, when either dialysis or transplantation becomes necessary for survival. Once renal function is impaired to less than about 25% of normal capacity, no matter what the aetiology, impairment tends to progress inexorably towards ESRD. However, even if a specific therapy for the renal disease is not available, there are many non-specific therapies that can be utilised to slow the tempo of renal deterioration. This review describes therapeutic initiatives that can be employed to minimise or slow down the progression of renal failure. These initiatives should be incorporated into an overall management strategy that addresses uraemic complications, control of comorbid disease and preparation for renal replacement therapy.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalCurrent Therapeutics
Issue number10
Publication statusPublished - 1 Oct 1999
Externally publishedYes

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