Sleep disruption, safety learning, and fear extinction in humans: Implications for posttraumatic stress disorder

Laura D. Straus, Sean P.A. Drummond, Victoria B. Risbrough, Sonya B. Norman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Fear learning is critical in the development and maintenance of posttraumatic stress disorder (PTSD) symptoms, and safety learning and extinction are necessary for recovery. Studies in animal models suggest that sleep disruption, and REM sleep fragmentation in particular, interfere with safety learning and extinction processes, and recently, studies are extending these findings to humans. A discussion of the human literature is presented here, which largely consists of experimental studies in healthy human control subjects. A theoretical model for the relationship between fear learning, sleep disruption, and impaired safety learning and extinction is proposed, which provides an explanatory framework for sleep disruption and its relationship to PTSD. Overall, findings suggest that sleep disruption plays a role in the development and maintenance of PTSD symptoms, and thus presents an important modifiable target in PTSD treatment.

Original languageEnglish
Title of host publicationBehavioral Neurobiology of PTSD
EditorsEric Vermetten, Dewleen G. Baker, Victoria B. Risbrough
PublisherSpringer
Pages193-205
Number of pages13
ISBN (Electronic)9783319948249
ISBN (Print)9783319948232
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameCurrent Topics in Behavioral Neurosciences
Volume38
ISSN (Print)1866-3370
ISSN (Electronic)1866-3389

Keywords

  • Fear learning
  • Posttraumatic stress disorder
  • Sleep

Cite this

Straus, L. D., Drummond, S. P. A., Risbrough, V. B., & Norman, S. B. (2018). Sleep disruption, safety learning, and fear extinction in humans: Implications for posttraumatic stress disorder. In E. Vermetten, D. G. Baker, & V. B. Risbrough (Eds.), Behavioral Neurobiology of PTSD (pp. 193-205). (Current Topics in Behavioral Neurosciences; Vol. 38). Springer. https://doi.org/10.1007/7854_2017_31
Straus, Laura D. ; Drummond, Sean P.A. ; Risbrough, Victoria B. ; Norman, Sonya B. / Sleep disruption, safety learning, and fear extinction in humans : Implications for posttraumatic stress disorder. Behavioral Neurobiology of PTSD. editor / Eric Vermetten ; Dewleen G. Baker ; Victoria B. Risbrough. Springer, 2018. pp. 193-205 (Current Topics in Behavioral Neurosciences).
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Straus, LD, Drummond, SPA, Risbrough, VB & Norman, SB 2018, Sleep disruption, safety learning, and fear extinction in humans: Implications for posttraumatic stress disorder. in E Vermetten, DG Baker & VB Risbrough (eds), Behavioral Neurobiology of PTSD. Current Topics in Behavioral Neurosciences, vol. 38, Springer, pp. 193-205. https://doi.org/10.1007/7854_2017_31

Sleep disruption, safety learning, and fear extinction in humans : Implications for posttraumatic stress disorder. / Straus, Laura D.; Drummond, Sean P.A.; Risbrough, Victoria B.; Norman, Sonya B.

Behavioral Neurobiology of PTSD. ed. / Eric Vermetten; Dewleen G. Baker; Victoria B. Risbrough. Springer, 2018. p. 193-205 (Current Topics in Behavioral Neurosciences; Vol. 38).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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Straus LD, Drummond SPA, Risbrough VB, Norman SB. Sleep disruption, safety learning, and fear extinction in humans: Implications for posttraumatic stress disorder. In Vermetten E, Baker DG, Risbrough VB, editors, Behavioral Neurobiology of PTSD. Springer. 2018. p. 193-205. (Current Topics in Behavioral Neurosciences). https://doi.org/10.1007/7854_2017_31