Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction

Laura D Straus, Dean T Acheson, Victoria B Risbrough, Sean P.A. Drummond

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Learned fear is crucial in the development and maintenance of posttraumatic stress disorder and other anxiety disorders, and extinction of learned fear is necessary for response to exposure-based treatments. In humans, research suggests that disrupted sleep impairs consolidation of extinction, though no studies have examined this experimentally using total sleep deprivation. Methods Seventy-one healthy control subjects underwent a paradigm to acquire conditioned fear to a visual cue. Twenty-four hours after fear conditioning, participants underwent extinction learning. Twenty-four hours after extinction learning, participants underwent extinction recall. Participants were randomized to three groups: 1) well-rested throughout testing (“normal sleep”; n = 21); 2) 36 hours’ total sleep deprivation before extinction learning (“pre-extinction deprivation”; n = 25); or 3) 36 hours’ total sleep deprivation after extinction learning and before extinction recall (“post-extinction deprivation”; n = 25). The groups were compared on blink electromyography reactivity to the condition stimulus during extinction learning and recall. Results There were no differences among the three groups during extinction learning. During extinction recall, the pre-extinction deprivation group demonstrated significantly less extinction recall than the normal sleep group did. There was no significant difference between the normal sleep and post-extinction deprivation group during extinction recall. Results indicated sleep deprivation before extinction training significantly disrupts extinction recall. Conclusions These findings suggest that 1) sleep deprivation in the immediate aftermath of trauma could be a potential contributor to posttraumatic stress disorder development and maintenance via interference with natural extinction processes and 2) management of sleep symptoms should be considered during extinction-based therapy.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Extinction
  • Fear conditioning
  • Fear potentiated startle
  • PTSD
  • REM sleep
  • Sleep deprivation

Cite this

Straus, Laura D ; Acheson, Dean T ; Risbrough, Victoria B ; Drummond, Sean P.A. / Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction. In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2017 ; Vol. 2, No. 2. pp. 123-129.
@article{3c02359a40f8480eb7439796acad4890,
title = "Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction",
abstract = "Background Learned fear is crucial in the development and maintenance of posttraumatic stress disorder and other anxiety disorders, and extinction of learned fear is necessary for response to exposure-based treatments. In humans, research suggests that disrupted sleep impairs consolidation of extinction, though no studies have examined this experimentally using total sleep deprivation. Methods Seventy-one healthy control subjects underwent a paradigm to acquire conditioned fear to a visual cue. Twenty-four hours after fear conditioning, participants underwent extinction learning. Twenty-four hours after extinction learning, participants underwent extinction recall. Participants were randomized to three groups: 1) well-rested throughout testing (“normal sleep”; n = 21); 2) 36 hours’ total sleep deprivation before extinction learning (“pre-extinction deprivation”; n = 25); or 3) 36 hours’ total sleep deprivation after extinction learning and before extinction recall (“post-extinction deprivation”; n = 25). The groups were compared on blink electromyography reactivity to the condition stimulus during extinction learning and recall. Results There were no differences among the three groups during extinction learning. During extinction recall, the pre-extinction deprivation group demonstrated significantly less extinction recall than the normal sleep group did. There was no significant difference between the normal sleep and post-extinction deprivation group during extinction recall. Results indicated sleep deprivation before extinction training significantly disrupts extinction recall. Conclusions These findings suggest that 1) sleep deprivation in the immediate aftermath of trauma could be a potential contributor to posttraumatic stress disorder development and maintenance via interference with natural extinction processes and 2) management of sleep symptoms should be considered during extinction-based therapy.",
keywords = "Extinction, Fear conditioning, Fear potentiated startle, PTSD, REM sleep, Sleep deprivation",
author = "Straus, {Laura D} and Acheson, {Dean T} and Risbrough, {Victoria B} and Drummond, {Sean P.A.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.bpsc.2016.05.004",
language = "English",
volume = "2",
pages = "123--129",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Academic Press",
number = "2",

}

Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction. / Straus, Laura D; Acheson, Dean T; Risbrough, Victoria B; Drummond, Sean P.A.

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 2, No. 2, 01.03.2017, p. 123-129.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction

AU - Straus, Laura D

AU - Acheson, Dean T

AU - Risbrough, Victoria B

AU - Drummond, Sean P.A.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background Learned fear is crucial in the development and maintenance of posttraumatic stress disorder and other anxiety disorders, and extinction of learned fear is necessary for response to exposure-based treatments. In humans, research suggests that disrupted sleep impairs consolidation of extinction, though no studies have examined this experimentally using total sleep deprivation. Methods Seventy-one healthy control subjects underwent a paradigm to acquire conditioned fear to a visual cue. Twenty-four hours after fear conditioning, participants underwent extinction learning. Twenty-four hours after extinction learning, participants underwent extinction recall. Participants were randomized to three groups: 1) well-rested throughout testing (“normal sleep”; n = 21); 2) 36 hours’ total sleep deprivation before extinction learning (“pre-extinction deprivation”; n = 25); or 3) 36 hours’ total sleep deprivation after extinction learning and before extinction recall (“post-extinction deprivation”; n = 25). The groups were compared on blink electromyography reactivity to the condition stimulus during extinction learning and recall. Results There were no differences among the three groups during extinction learning. During extinction recall, the pre-extinction deprivation group demonstrated significantly less extinction recall than the normal sleep group did. There was no significant difference between the normal sleep and post-extinction deprivation group during extinction recall. Results indicated sleep deprivation before extinction training significantly disrupts extinction recall. Conclusions These findings suggest that 1) sleep deprivation in the immediate aftermath of trauma could be a potential contributor to posttraumatic stress disorder development and maintenance via interference with natural extinction processes and 2) management of sleep symptoms should be considered during extinction-based therapy.

AB - Background Learned fear is crucial in the development and maintenance of posttraumatic stress disorder and other anxiety disorders, and extinction of learned fear is necessary for response to exposure-based treatments. In humans, research suggests that disrupted sleep impairs consolidation of extinction, though no studies have examined this experimentally using total sleep deprivation. Methods Seventy-one healthy control subjects underwent a paradigm to acquire conditioned fear to a visual cue. Twenty-four hours after fear conditioning, participants underwent extinction learning. Twenty-four hours after extinction learning, participants underwent extinction recall. Participants were randomized to three groups: 1) well-rested throughout testing (“normal sleep”; n = 21); 2) 36 hours’ total sleep deprivation before extinction learning (“pre-extinction deprivation”; n = 25); or 3) 36 hours’ total sleep deprivation after extinction learning and before extinction recall (“post-extinction deprivation”; n = 25). The groups were compared on blink electromyography reactivity to the condition stimulus during extinction learning and recall. Results There were no differences among the three groups during extinction learning. During extinction recall, the pre-extinction deprivation group demonstrated significantly less extinction recall than the normal sleep group did. There was no significant difference between the normal sleep and post-extinction deprivation group during extinction recall. Results indicated sleep deprivation before extinction training significantly disrupts extinction recall. Conclusions These findings suggest that 1) sleep deprivation in the immediate aftermath of trauma could be a potential contributor to posttraumatic stress disorder development and maintenance via interference with natural extinction processes and 2) management of sleep symptoms should be considered during extinction-based therapy.

KW - Extinction

KW - Fear conditioning

KW - Fear potentiated startle

KW - PTSD

KW - REM sleep

KW - Sleep deprivation

UR - http://www.scopus.com/inward/record.url?scp=84999663698&partnerID=8YFLogxK

U2 - 10.1016/j.bpsc.2016.05.004

DO - 10.1016/j.bpsc.2016.05.004

M3 - Article

VL - 2

SP - 123

EP - 129

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

SN - 2451-9022

IS - 2

ER -