Sizing up the key determinants of the CD8 T cell response

David C Tscharke, Nathan P Croft, Peter C Doherty, Nicole L La Gruta

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Naive CD8+ T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective eradication of viruses and tumours. Although the past decades have seen enormous advances in cellular immunology, a precise understanding of the key elements that determine the specificity and magnitude of primary CTL responses has been lacking. However, recent technological advances have allowed us to more accurately identify, characterize and quantitate key determinants that define the specificity and magnitude of CD8+ T cell-mediated immunity. This Review discusses the technical and conceptual advances that have markedly changed our understanding of the determinants of primary CTL responses.
Original languageEnglish
Pages (from-to)705 - 716
Number of pages12
JournalNature Reviews Immunology
Volume15
Issue number11
DOIs
Publication statusPublished - 2015

Cite this

Tscharke, David C ; Croft, Nathan P ; Doherty, Peter C ; La Gruta, Nicole L. / Sizing up the key determinants of the CD8 T cell response. In: Nature Reviews Immunology. 2015 ; Vol. 15, No. 11. pp. 705 - 716.
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Sizing up the key determinants of the CD8 T cell response. / Tscharke, David C; Croft, Nathan P; Doherty, Peter C; La Gruta, Nicole L.

In: Nature Reviews Immunology, Vol. 15, No. 11, 2015, p. 705 - 716.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Naive CD8+ T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective eradication of viruses and tumours. Although the past decades have seen enormous advances in cellular immunology, a precise understanding of the key elements that determine the specificity and magnitude of primary CTL responses has been lacking. However, recent technological advances have allowed us to more accurately identify, characterize and quantitate key determinants that define the specificity and magnitude of CD8+ T cell-mediated immunity. This Review discusses the technical and conceptual advances that have markedly changed our understanding of the determinants of primary CTL responses.

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