Six-minute walk distance in patients with chronic obstructive pulmonary disease: Which reference equations should we use?

Vasileios Andrianopoulos, Anne E. Holland, Sally J. Singh, Frits M.E. Franssen, Herman-Jan Pennings, Arent J. Michels, Frank W.J.M. Smeenk, Ioannis Vogiatzis, Emiel F.M. Wouters, Martijn A. Spruit

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

The use of different 6-min walk distance (6MWD) reference equations probably results in different predicted 6MWD reference values. We wished to investigate the impact of several 6MWD reference equations for adults in patients with chronic obstructive pulmonary disease (COPD) and factors accountable for different 6MWD% predicted values. Twenty-two 6MWD reference equations were applied to a data set of 2757 patients with COPD. The predicted 6MWD reference value of Troosters and colleagues was used as the point of reference. Four out of 21 remaining equations resulted in comparable 6MWD% predicted, 16 equations resulted in significantly higher 6MWD% predicted and 1 equation resulted in a significantly lower 6MWD% predicted. Similar differences in 6MWD% predicted were observed after stratification by sex. Body mass index and global initiative for chronic obstructive lung disease (GOLD) stage classification demonstrated varying results within and between the groups; 9 out of 21 equations resulted in comparable 6MWD% predicted in underweight patients but only 1 equation demonstrated comparable result in obese. Eight equations in GOLD I, whilst 5 out of 21 equations in GOLD IV resulted in comparable 6MWD% predicted. Existing 6MWD reference equations will give varying results. The choice of 6MWD reference equation should consider the consistency of 6-min walk test operating procedures and at least be specific for the country/region of origin.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalChronic Respiratory Disease
Volume12
Issue number2
DOIs
Publication statusPublished - 4 May 2015
Externally publishedYes

Keywords

  • 6-min walk test
  • 6MWD predicted values
  • 6MWD reference equations
  • COPD
  • exercise capacity

Cite this

Andrianopoulos, Vasileios ; Holland, Anne E. ; Singh, Sally J. ; Franssen, Frits M.E. ; Pennings, Herman-Jan ; Michels, Arent J. ; Smeenk, Frank W.J.M. ; Vogiatzis, Ioannis ; Wouters, Emiel F.M. ; Spruit, Martijn A. / Six-minute walk distance in patients with chronic obstructive pulmonary disease : Which reference equations should we use?. In: Chronic Respiratory Disease. 2015 ; Vol. 12, No. 2. pp. 111-119.
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abstract = "The use of different 6-min walk distance (6MWD) reference equations probably results in different predicted 6MWD reference values. We wished to investigate the impact of several 6MWD reference equations for adults in patients with chronic obstructive pulmonary disease (COPD) and factors accountable for different 6MWD{\%} predicted values. Twenty-two 6MWD reference equations were applied to a data set of 2757 patients with COPD. The predicted 6MWD reference value of Troosters and colleagues was used as the point of reference. Four out of 21 remaining equations resulted in comparable 6MWD{\%} predicted, 16 equations resulted in significantly higher 6MWD{\%} predicted and 1 equation resulted in a significantly lower 6MWD{\%} predicted. Similar differences in 6MWD{\%} predicted were observed after stratification by sex. Body mass index and global initiative for chronic obstructive lung disease (GOLD) stage classification demonstrated varying results within and between the groups; 9 out of 21 equations resulted in comparable 6MWD{\%} predicted in underweight patients but only 1 equation demonstrated comparable result in obese. Eight equations in GOLD I, whilst 5 out of 21 equations in GOLD IV resulted in comparable 6MWD{\%} predicted. Existing 6MWD reference equations will give varying results. The choice of 6MWD reference equation should consider the consistency of 6-min walk test operating procedures and at least be specific for the country/region of origin.",
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author = "Vasileios Andrianopoulos and Holland, {Anne E.} and Singh, {Sally J.} and Franssen, {Frits M.E.} and Herman-Jan Pennings and Michels, {Arent J.} and Smeenk, {Frank W.J.M.} and Ioannis Vogiatzis and Wouters, {Emiel F.M.} and Spruit, {Martijn A.}",
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Andrianopoulos, V, Holland, AE, Singh, SJ, Franssen, FME, Pennings, H-J, Michels, AJ, Smeenk, FWJM, Vogiatzis, I, Wouters, EFM & Spruit, MA 2015, 'Six-minute walk distance in patients with chronic obstructive pulmonary disease: Which reference equations should we use?', Chronic Respiratory Disease, vol. 12, no. 2, pp. 111-119. https://doi.org/10.1177/1479972315575201

Six-minute walk distance in patients with chronic obstructive pulmonary disease : Which reference equations should we use? / Andrianopoulos, Vasileios; Holland, Anne E.; Singh, Sally J.; Franssen, Frits M.E.; Pennings, Herman-Jan; Michels, Arent J.; Smeenk, Frank W.J.M.; Vogiatzis, Ioannis; Wouters, Emiel F.M.; Spruit, Martijn A.

In: Chronic Respiratory Disease, Vol. 12, No. 2, 04.05.2015, p. 111-119.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Pennings, Herman-Jan

AU - Michels, Arent J.

AU - Smeenk, Frank W.J.M.

AU - Vogiatzis, Ioannis

AU - Wouters, Emiel F.M.

AU - Spruit, Martijn A.

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