Sitagliptin: is it effective in routine clinical practice?

Rita Mohan Dallumal, Siew Siang Chua, David Bin Chia Wu, Shireene Ratna Vethakkan

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    Abstract

    Aim. The present study was conducted to determine the glycaemic effects of sitagliptin in type 2 diabetes patients. Methods. Data was collected from patient medical records of a major teaching hospital in Malaysia, from 2009 to 2012. Glycated hemoglobin (HbA1c) values prior to and up to 12 months after the initiation of sitagliptin were analysed. The change in HbA1c values was accounted for based on a generalized linear model generated using the Generalized Estimating Equations (GEE) method. Results and Discussion. Of the 457 patients, 53.6 were elderly and 81.4 were overweight. The mean HbA1c (standard deviation) before initiation of sitagliptin was 8.5 (1.4) . This dropped to 7.7 (1.4) , 3 to 6 months after initiation of sitagliptin, with a mean difference of 0.8 (95 confidence interval (CI): 0.7-1.0; P
    Original languageEnglish
    Pages (from-to)1 - 9
    Number of pages9
    JournalInternational Journal of Endocrinology
    Volume2015
    DOIs
    Publication statusPublished - 2015

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