Singlet oxygen formation in monomeric and aggregated porphyrin c

L. E. Bennett, K. P. Ghiggino, R. W. Henderson

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Abstract

The absorption and fluorescence spectra of monomeric and aggregated species present in aqueous solutions of porphyrin c have been resolved by steady-state and time-resolved spectroscopy. The dependence of the singlet oxygen formation yield φΔ on excitation wavelength has also been determined. In the Q-band spectral region, the aggregate absorption and emission spectra are shifted to longer wavelengths with respect to the monomer spectrum with φΔ (monomer)= 0.59 and φΔ(aggregate) = 0.33. The relevance of these findings to the optimization of irradiation conditions in tumour phototherapy using porphyrin c are discussed.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalJournal of Photochemistry and Photobiology, B: Biology
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Jan 1989
Externally publishedYes

Keywords

  • aggregation
  • fluorescence
  • photosensitizer
  • phototherapy.
  • Porphyrin c
  • singlet oxygen
  • time-resolved spectroscopy

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