Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover

Elisabeth Lambert, Markus P Schlaich, Tye Dawood, Carolina I Sari, Reena Chopra, David A Barton, David M Kaye, Mikael Elam, Murray D Esler, Gavin Lambert

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44 Citations (Scopus)

Abstract

Recent work using single-unit sympathetic nerve recording techniques has demonstrated aberrations in the firing pattern of sympathetic nerves in a variety of patient groups. We sought to examine whether nerve firing pattern is associated with increased noradrenaline release. Using single-unit muscle sympathetic nerve recording techniques coupled with direct cardiac catheterisation and noradrenaline isotope dilution methodology we examined the relationship between single-unit firing patterns and cardiac and whole body noradrenaline spillover to plasma. Participants comprised patients with hypertension (n=6), depression (n=7) and panic disorder (n =9) who were drawn from our ongoing studies. The patient groups examined did not differ in their single-unit muscle sympathetic nerve firing characteristics nor in the rate of spillover of noradrenaline to plasma from the heart. The median incidence of multiple spikes per beat was 9 . Patients were stratified according to the firing pattern: low level of incidence (less than 9 incidence of multiple spikes per beat) and high level of incidence (greater than 9 incidence of multiple spikes per beat). High incidence of multiple spikes within a cardiac cycle was associated with higher firing rates (P
Original languageEnglish
Pages (from-to)2597 - 2605
Number of pages9
JournalThe Journal of Physiology
Volume589
Issue numberPt. 10
DOIs
Publication statusPublished - 2011

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