Single-shot X-ray measurement of alveolar size distributions

Richard P. Carnibella, Marcus J Kitchen, Andreas Fouras

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

4 Citations (Scopus)


Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies. 

Original languageEnglish
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsRobert C. Molthen, John B. Weaver
Place of PublicationBellingham WA USA
Number of pages7
ISBN (Print)9780819498311
Publication statusPublished - 15 Feb 2014
EventConference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014 - San Diego, United States of America
Duration: 16 Feb 201418 Feb 2014 (Proceedings)

Publication series

NameProgress in Biomedical Optics and Imaging
ISSN (Print)1605-7422


ConferenceConference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014
Country/TerritoryUnited States of America
CitySan Diego
Internet address


  • Alveolar size
  • Dynamic imaging
  • Functional imaging
  • Lung imaging
  • Phase contrast
  • X-ray imaging

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