Single-shot X-ray measurement of alveolar size distributions

Richard P. Carnibella, Marcus J Kitchen, Andreas Fouras

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies. 

Original languageEnglish
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsRobert C. Molthen, John B. Weaver
Place of PublicationBellingham WA USA
PublisherSPIE
Number of pages7
Volume9038
ISBN (Print)9780819498311
DOIs
Publication statusPublished - 15 Feb 2014
EventConference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014 - San Diego, United States of America
Duration: 16 Feb 201418 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging
PublisherSPIE
Number39
Volume15
ISSN (Print)1605-7422

Conference

ConferenceConference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014
CountryUnited States of America
CitySan Diego
Period16/02/1418/02/14

Keywords

  • Alveolar size
  • Dynamic imaging
  • Functional imaging
  • Lung imaging
  • Phase contrast
  • X-ray imaging

Cite this

Carnibella, R. P., Kitchen, M. J., & Fouras, A. (2014). Single-shot X-ray measurement of alveolar size distributions. In R. C. Molthen, & J. B. Weaver (Eds.), Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 9038). [90380V] (Progress in Biomedical Optics and Imaging; Vol. 15, No. 39). Bellingham WA USA: SPIE. https://doi.org/10.1117/12.2043415
Carnibella, Richard P. ; Kitchen, Marcus J ; Fouras, Andreas. / Single-shot X-ray measurement of alveolar size distributions. Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Robert C. Molthen ; John B. Weaver. Vol. 9038 Bellingham WA USA : SPIE, 2014. (Progress in Biomedical Optics and Imaging; 39).
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Carnibella, RP, Kitchen, MJ & Fouras, A 2014, Single-shot X-ray measurement of alveolar size distributions. in RC Molthen & JB Weaver (eds), Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 9038, 90380V, Progress in Biomedical Optics and Imaging, no. 39, vol. 15, SPIE, Bellingham WA USA, Conference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014, San Diego, United States of America, 16/02/14. https://doi.org/10.1117/12.2043415

Single-shot X-ray measurement of alveolar size distributions. / Carnibella, Richard P.; Kitchen, Marcus J; Fouras, Andreas.

Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Robert C. Molthen; John B. Weaver. Vol. 9038 Bellingham WA USA : SPIE, 2014. 90380V (Progress in Biomedical Optics and Imaging; Vol. 15, No. 39).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AB - Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies. 

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Carnibella RP, Kitchen MJ, Fouras A. Single-shot X-ray measurement of alveolar size distributions. In Molthen RC, Weaver JB, editors, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9038. Bellingham WA USA: SPIE. 2014. 90380V. (Progress in Biomedical Optics and Imaging; 39). https://doi.org/10.1117/12.2043415