Single-shot X-ray measurement of alveolar size distributions

Richard P. Carnibella; Marcus J Kitchen; Andreas Fouras

doi:10.1117/12.2043415

Single-shot X-ray measurement of alveolar size distributions

Richard P. Carnibella, Marcus J Kitchen, Andreas Fouras

Mechanical & Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

4 Citations (Scopus)

Abstract

Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies.

Original language	English
Title of host publication	Medical Imaging 2014
Subtitle of host publication	Biomedical Applications in Molecular, Structural, and Functional Imaging
Editors	Robert C. Molthen, John B. Weaver
Place of Publication	Bellingham WA USA
Publisher	SPIE - International Society for Optical Engineering
Number of pages	7
Volume	9038
ISBN (Print)	9780819498311
DOIs	https://doi.org/10.1117/12.2043415
Publication status	Published - 15 Feb 2014
Event	Conference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014 - San Diego, United States of America Duration: 16 Feb 2014 → 18 Feb 2014 https://spie.org/Publications/Proceedings/Volume/9038 (Proceedings)

Publication series

Name	Progress in Biomedical Optics and Imaging
Publisher	SPIE
Number	39
Volume	15
ISSN (Print)	1605-7422

Conference

Conference	Conference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014
Country/Territory	United States of America
City	San Diego
Period	16/02/14 → 18/02/14
Internet address	https://spie.org/Publications/Proceedings/Volume/9038 (Proceedings)

Keywords

Alveolar size
Dynamic imaging
Functional imaging
Lung imaging
Phase contrast
X-ray imaging

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10.1117/12.2043415

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Carnibella, R. P., Kitchen, M. J., & Fouras, A. (2014). Single-shot X-ray measurement of alveolar size distributions. In R. C. Molthen, & J. B. Weaver (Eds.), Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 9038). Article 90380V (Progress in Biomedical Optics and Imaging; Vol. 15, No. 39). SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2043415

Carnibella, Richard P. ; Kitchen, Marcus J ; Fouras, Andreas. / Single-shot X-ray measurement of alveolar size distributions. Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Robert C. Molthen ; John B. Weaver. Vol. 9038 Bellingham WA USA : SPIE - International Society for Optical Engineering, 2014. (Progress in Biomedical Optics and Imaging; 39).

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abstract = "Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies. ",

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Carnibella, RP, Kitchen, MJ & Fouras, A 2014, Single-shot X-ray measurement of alveolar size distributions. in RC Molthen & JB Weaver (eds), Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 9038, 90380V, Progress in Biomedical Optics and Imaging, no. 39, vol. 15, SPIE - International Society for Optical Engineering, Bellingham WA USA, Conference on Medical Imaging - Biomedical Applications in Molecular, Structural, and Functional Imaging 2014, San Diego, California, United States of America, 16/02/14. https://doi.org/10.1117/12.2043415

Single-shot X-ray measurement of alveolar size distributions. / Carnibella, Richard P.; Kitchen, Marcus J; Fouras, Andreas.
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Robert C. Molthen; John B. Weaver. Vol. 9038 Bellingham WA USA: SPIE - International Society for Optical Engineering, 2014. 90380V (Progress in Biomedical Optics and Imaging; Vol. 15, No. 39).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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N2 - Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies.

AB - Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pupa's lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies.

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KW - Functional imaging

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Carnibella RP, Kitchen MJ, Fouras A. Single-shot X-ray measurement of alveolar size distributions. In Molthen RC, Weaver JB, editors, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9038. Bellingham WA USA: SPIE - International Society for Optical Engineering. 2014. 90380V. (Progress in Biomedical Optics and Imaging; 39). doi: 10.1117/12.2043415

Single-shot X-ray measurement of alveolar size distributions

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Keywords

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