Single pulse transcranial magnetic stimulation-electroencephalogram reveals no electrophysiological abnormality in adults with high-functioning autism spectrum disorder

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Objective: Neuroimaging and electrophysiological research have revealed a range of neural abnormalities in autism spectrum disorder (ASD), but a comprehensive understanding remains elusive. We utilized a novel methodology among individuals with ASD and matched controls, combining transcranial magnetic stimulation (TMS) with concurrent electroencephalogram (EEG) recording (TMS-EEG) to explore cortical function and connectivity in three sites implicated in the neuropathophysiology of ASD (dorsolateral prefrontal cortex, primary motor cortex, and temporoparietal junction). As there is evidence for neurobiological gender differences in ASD, we also examined the influence of biological sex. 

Methods: TMS pulses were applied to each of the three sites (right lateralized) during 20-channel EEG recording. Results: We did not identify any differences in the EEG response to TMS between ASD and control groups. This finding remained when data were stratified by sex. Nevertheless, traits and characteristics associated with ASD were correlated with the neurophysiological response to TMS. 

Conclusion: While TMS-EEG did not appear to clarify the neuropathophysiology of ASD, the relationships identified between the neurophysiological response to TMS and clinical characteristics warrant further investigation.

Original languageEnglish
Pages (from-to)606-616
Number of pages11
JournalJournal of Child and Adolescent Psychopharmacology
Volume26
Issue number7
DOIs
Publication statusPublished - 1 Sep 2016

Cite this

@article{9c3c5cc1c9bb459da5ed294b12521a38,
title = "Single pulse transcranial magnetic stimulation-electroencephalogram reveals no electrophysiological abnormality in adults with high-functioning autism spectrum disorder",
abstract = "Objective: Neuroimaging and electrophysiological research have revealed a range of neural abnormalities in autism spectrum disorder (ASD), but a comprehensive understanding remains elusive. We utilized a novel methodology among individuals with ASD and matched controls, combining transcranial magnetic stimulation (TMS) with concurrent electroencephalogram (EEG) recording (TMS-EEG) to explore cortical function and connectivity in three sites implicated in the neuropathophysiology of ASD (dorsolateral prefrontal cortex, primary motor cortex, and temporoparietal junction). As there is evidence for neurobiological gender differences in ASD, we also examined the influence of biological sex. Methods: TMS pulses were applied to each of the three sites (right lateralized) during 20-channel EEG recording. Results: We did not identify any differences in the EEG response to TMS between ASD and control groups. This finding remained when data were stratified by sex. Nevertheless, traits and characteristics associated with ASD were correlated with the neurophysiological response to TMS. Conclusion: While TMS-EEG did not appear to clarify the neuropathophysiology of ASD, the relationships identified between the neurophysiological response to TMS and clinical characteristics warrant further investigation.",
author = "Melissa Kirkovski and Rogasch, {Nigel C.} and Takashi Saeki and Bernadette Fitzgibbon and Peter Enticott and Paul Fitzgerald",
year = "2016",
month = "9",
day = "1",
doi = "10.1089/cap.2015.0181",
language = "English",
volume = "26",
pages = "606--616",
journal = "Journal of Child and Adolescent Psychopharmacology",
issn = "1044-5463",
publisher = "Mary Ann Liebert Inc",
number = "7",

}

TY - JOUR

T1 - Single pulse transcranial magnetic stimulation-electroencephalogram reveals no electrophysiological abnormality in adults with high-functioning autism spectrum disorder

AU - Kirkovski, Melissa

AU - Rogasch, Nigel C.

AU - Saeki, Takashi

AU - Fitzgibbon, Bernadette

AU - Enticott, Peter

AU - Fitzgerald, Paul

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objective: Neuroimaging and electrophysiological research have revealed a range of neural abnormalities in autism spectrum disorder (ASD), but a comprehensive understanding remains elusive. We utilized a novel methodology among individuals with ASD and matched controls, combining transcranial magnetic stimulation (TMS) with concurrent electroencephalogram (EEG) recording (TMS-EEG) to explore cortical function and connectivity in three sites implicated in the neuropathophysiology of ASD (dorsolateral prefrontal cortex, primary motor cortex, and temporoparietal junction). As there is evidence for neurobiological gender differences in ASD, we also examined the influence of biological sex. Methods: TMS pulses were applied to each of the three sites (right lateralized) during 20-channel EEG recording. Results: We did not identify any differences in the EEG response to TMS between ASD and control groups. This finding remained when data were stratified by sex. Nevertheless, traits and characteristics associated with ASD were correlated with the neurophysiological response to TMS. Conclusion: While TMS-EEG did not appear to clarify the neuropathophysiology of ASD, the relationships identified between the neurophysiological response to TMS and clinical characteristics warrant further investigation.

AB - Objective: Neuroimaging and electrophysiological research have revealed a range of neural abnormalities in autism spectrum disorder (ASD), but a comprehensive understanding remains elusive. We utilized a novel methodology among individuals with ASD and matched controls, combining transcranial magnetic stimulation (TMS) with concurrent electroencephalogram (EEG) recording (TMS-EEG) to explore cortical function and connectivity in three sites implicated in the neuropathophysiology of ASD (dorsolateral prefrontal cortex, primary motor cortex, and temporoparietal junction). As there is evidence for neurobiological gender differences in ASD, we also examined the influence of biological sex. Methods: TMS pulses were applied to each of the three sites (right lateralized) during 20-channel EEG recording. Results: We did not identify any differences in the EEG response to TMS between ASD and control groups. This finding remained when data were stratified by sex. Nevertheless, traits and characteristics associated with ASD were correlated with the neurophysiological response to TMS. Conclusion: While TMS-EEG did not appear to clarify the neuropathophysiology of ASD, the relationships identified between the neurophysiological response to TMS and clinical characteristics warrant further investigation.

UR - http://www.scopus.com/inward/record.url?scp=84988564524&partnerID=8YFLogxK

U2 - 10.1089/cap.2015.0181

DO - 10.1089/cap.2015.0181

M3 - Article

VL - 26

SP - 606

EP - 616

JO - Journal of Child and Adolescent Psychopharmacology

JF - Journal of Child and Adolescent Psychopharmacology

SN - 1044-5463

IS - 7

ER -