Single Nanochannel-Aptamer-Based Biosensor for Ultrasensitive and Selective Cocaine Detection

Jian Wang, Jue Hou, Huacheng Zhang, Ye Tian, Lei Jiang

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)


Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an excellent sensitivity and good selectivity. A linear relationship between target cocaine concentration and output ionic current is obtained in a wide concentration range of cocaine from 1 nM to 10 μM. The cocaine sensor also shows a detection limit down to 1 nM. This study provides a new avenue to develop new nanochannel-aptamer-based biosensors for rapid and ultratrace detection of a variety of illicit drugs.

Original languageEnglish
Pages (from-to)2033-2039
Number of pages7
JournalACS Applied Materials & Interfaces
Issue number2
Publication statusPublished - 17 Jan 2018


  • biosensor
  • cocaine detection
  • DNA aptamers
  • drug testing
  • nanochannel sensor

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