Abstract
Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an excellent sensitivity and good selectivity. A linear relationship between target cocaine concentration and output ionic current is obtained in a wide concentration range of cocaine from 1 nM to 10 μM. The cocaine sensor also shows a detection limit down to 1 nM. This study provides a new avenue to develop new nanochannel-aptamer-based biosensors for rapid and ultratrace detection of a variety of illicit drugs.
Original language | English |
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Pages (from-to) | 2033-2039 |
Number of pages | 7 |
Journal | ACS Applied Materials & Interfaces |
Volume | 10 |
Issue number | 2 |
DOIs | |
Publication status | Published - 17 Jan 2018 |
Keywords
- biosensor
- cocaine detection
- DNA aptamers
- drug testing
- nanochannel sensor