Abstract
Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an excellent sensitivity and good selectivity. A linear relationship between target cocaine concentration and output ionic current is obtained in a wide concentration range of cocaine from 1 nM to 10 μM. The cocaine sensor also shows a detection limit down to 1 nM. This study provides a new avenue to develop new nanochannel-aptamer-based biosensors for rapid and ultratrace detection of a variety of illicit drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 2033-2039 |
| Number of pages | 7 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 17 Jan 2018 |
Keywords
- biosensor
- cocaine detection
- DNA aptamers
- drug testing
- nanochannel sensor
Cite this
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Single Nanochannel-Aptamer-Based Biosensor for Ultrasensitive and Selective Cocaine Detection. / Wang, Jian; Hou, Jue; Zhang, Huacheng; Tian, Ye; Jiang, Lei.
In: ACS Applied Materials and Interfaces, Vol. 10, No. 2, 17.01.2018, p. 2033-2039.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Single Nanochannel-Aptamer-Based Biosensor for Ultrasensitive and Selective Cocaine Detection
AU - Wang, Jian
AU - Hou, Jue
AU - Zhang, Huacheng
AU - Tian, Ye
AU - Jiang, Lei
PY - 2018/1/17
Y1 - 2018/1/17
N2 - Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an excellent sensitivity and good selectivity. A linear relationship between target cocaine concentration and output ionic current is obtained in a wide concentration range of cocaine from 1 nM to 10 μM. The cocaine sensor also shows a detection limit down to 1 nM. This study provides a new avenue to develop new nanochannel-aptamer-based biosensors for rapid and ultratrace detection of a variety of illicit drugs.
AB - Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an excellent sensitivity and good selectivity. A linear relationship between target cocaine concentration and output ionic current is obtained in a wide concentration range of cocaine from 1 nM to 10 μM. The cocaine sensor also shows a detection limit down to 1 nM. This study provides a new avenue to develop new nanochannel-aptamer-based biosensors for rapid and ultratrace detection of a variety of illicit drugs.
KW - biosensor
KW - cocaine detection
KW - DNA aptamers
KW - drug testing
KW - nanochannel sensor
UR - http://www.scopus.com/inward/record.url?scp=85040720930&partnerID=8YFLogxK
U2 - 10.1021/acsami.7b16539
DO - 10.1021/acsami.7b16539
M3 - Article
VL - 10
SP - 2033
EP - 2039
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
SN - 1944-8244
IS - 2
ER -