Single-molecule study of dendrimer-hydrocarbon interaction

Karthikeyan Pasupathy, Aaron T. Jones, Pu Chun Ke

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

In this paper we report our study on the interaction of dendrimer and hydrocarbon. The absorbance of generation-3 dendrimer PAMAM (0.25%) was reduced by ∼5% in 60 min with the addition of hydrocarbon Squalane (0.405 mg/mL), possibly due to the phase separation between the PAMAM remained in the solution and the PAMAM bound to the Squalane. Using single-molecule fluorescence microscopy we found that PAMAM molecules in the solution could be immobilized by Squalane molecules coated on a glass substrate, as indicated by the much increased fluorescence intensity of the TRITC-labeled PAMAM in an evanescent wave field. Our study offers the first evidence at the single-molecule level on dendrimer and hydrocarbon interaction and facilitates our understanding of using dendrimers for the prevention of gas hydrates for the petroleum industry.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages283-286
Number of pages4
Volume1
Publication statusPublished - 24 Aug 2007
Externally publishedYes
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, United States of America
Duration: 20 May 200724 May 2007

Conference

Conference2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States of America
CitySanta Clara
Period20/05/0724/05/07

Keywords

  • Fluorescence
  • PAMAM
  • Squalane

Cite this

Pasupathy, K., Jones, A. T., & Ke, P. C. (2007). Single-molecule study of dendrimer-hydrocarbon interaction. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (Vol. 1, pp. 283-286)