Single-molecule study of dendrimer-hydrocarbon interaction

Karthikeyan Pasupathy, Aaron T. Jones, Pu Chun Ke

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review


In this paper we report our study on the interaction of dendrimer and hydrocarbon. The absorbance of generation-3 dendrimer PAMAM (0.25%) was reduced by ∼5% in 60 min with the addition of hydrocarbon Squalane (0.405 mg/mL), possibly due to the phase separation between the PAMAM remained in the solution and the PAMAM bound to the Squalane. Using single-molecule fluorescence microscopy we found that PAMAM molecules in the solution could be immobilized by Squalane molecules coated on a glass substrate, as indicated by the much increased fluorescence intensity of the TRITC-labeled PAMAM in an evanescent wave field. Our study offers the first evidence at the single-molecule level on dendrimer and hydrocarbon interaction and facilitates our understanding of using dendrimers for the prevention of gas hydrates for the petroleum industry.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Number of pages4
Publication statusPublished - 24 Aug 2007
Externally publishedYes
EventNanotechnology Conference and Trade Show (Nanotech) 2007 - Santa Clara, United States of America
Duration: 20 May 200724 May 2007


ConferenceNanotechnology Conference and Trade Show (Nanotech) 2007
Abbreviated titleNSTI Nanotech 2007
Country/TerritoryUnited States of America
CitySanta Clara


  • Fluorescence
  • Squalane

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