Single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy

Jin-Shan Zhang, Long Li, Wei Cheng

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Single incision laparoscopic surgery as a surgical approach in treatment of pancreatic disease has recently been reported in adults. However, its application in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) in children is limited. In this article, we report single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. Between July 2011 and February 2015, the single incision laparoscopic 90 % pancreatectomy was performed in three children with PHHI. All patients underwent 18F-FDOPA PET/CT before the surgeries. The scans showed diffuse physiologic 18F-FDOPA activity in entire pancreas. All patients were followed up. The levels of blood sugar and insulin were recorded postoperatively. The time required for surgery was 120–230 min, and blood loss was minimal. The hospital stay was 6 days. The duration of postoperative abdominal drainage was 4–5 days. The levels of fasting blood glucose after surgery were higher than those before surgery (4.38–8.9 vs. 0.54–1.8 mmol/L). The levels of fasting insulin after surgery were lower than those before surgery (2.4–5.5 vs. 14–33.3 uU/ml). The duration of follow-up was 4–46 months. During follow-up, the levels of blood glucose and insulin were normal in three patients. There was no recurrence of hypoglycemia after operation in all patients. Single incision laparoscopic 90 % pancreatectomy for children with PHHI is feasible and safe in well-selected cases in the experienced centers.

Original languageEnglish
Pages (from-to)1003-1007
Number of pages5
JournalPediatric Surgery International
Volume32
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Children
  • Hyperinsulinemia
  • Hypoglycemia
  • SILS

Cite this

@article{50b6e13fbacd48e7872bce7b73ea30bc,
title = "Single incision laparoscopic 90 {\%} pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy",
abstract = "Single incision laparoscopic surgery as a surgical approach in treatment of pancreatic disease has recently been reported in adults. However, its application in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) in children is limited. In this article, we report single incision laparoscopic 90 {\%} pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. Between July 2011 and February 2015, the single incision laparoscopic 90 {\%} pancreatectomy was performed in three children with PHHI. All patients underwent 18F-FDOPA PET/CT before the surgeries. The scans showed diffuse physiologic 18F-FDOPA activity in entire pancreas. All patients were followed up. The levels of blood sugar and insulin were recorded postoperatively. The time required for surgery was 120–230 min, and blood loss was minimal. The hospital stay was 6 days. The duration of postoperative abdominal drainage was 4–5 days. The levels of fasting blood glucose after surgery were higher than those before surgery (4.38–8.9 vs. 0.54–1.8 mmol/L). The levels of fasting insulin after surgery were lower than those before surgery (2.4–5.5 vs. 14–33.3 uU/ml). The duration of follow-up was 4–46 months. During follow-up, the levels of blood glucose and insulin were normal in three patients. There was no recurrence of hypoglycemia after operation in all patients. Single incision laparoscopic 90 {\%} pancreatectomy for children with PHHI is feasible and safe in well-selected cases in the experienced centers.",
keywords = "Children, Hyperinsulinemia, Hypoglycemia, SILS",
author = "Jin-Shan Zhang and Long Li and Wei Cheng",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/s00383-016-3943-9",
language = "English",
volume = "32",
pages = "1003--1007",
journal = "Pediatric Surgery International",
issn = "0179-0358",
publisher = "Springer-Verlag London Ltd.",
number = "10",

}

Single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. / Zhang, Jin-Shan; Li, Long; Cheng, Wei.

In: Pediatric Surgery International, Vol. 32, No. 10, 01.10.2016, p. 1003-1007.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy

AU - Zhang, Jin-Shan

AU - Li, Long

AU - Cheng, Wei

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Single incision laparoscopic surgery as a surgical approach in treatment of pancreatic disease has recently been reported in adults. However, its application in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) in children is limited. In this article, we report single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. Between July 2011 and February 2015, the single incision laparoscopic 90 % pancreatectomy was performed in three children with PHHI. All patients underwent 18F-FDOPA PET/CT before the surgeries. The scans showed diffuse physiologic 18F-FDOPA activity in entire pancreas. All patients were followed up. The levels of blood sugar and insulin were recorded postoperatively. The time required for surgery was 120–230 min, and blood loss was minimal. The hospital stay was 6 days. The duration of postoperative abdominal drainage was 4–5 days. The levels of fasting blood glucose after surgery were higher than those before surgery (4.38–8.9 vs. 0.54–1.8 mmol/L). The levels of fasting insulin after surgery were lower than those before surgery (2.4–5.5 vs. 14–33.3 uU/ml). The duration of follow-up was 4–46 months. During follow-up, the levels of blood glucose and insulin were normal in three patients. There was no recurrence of hypoglycemia after operation in all patients. Single incision laparoscopic 90 % pancreatectomy for children with PHHI is feasible and safe in well-selected cases in the experienced centers.

AB - Single incision laparoscopic surgery as a surgical approach in treatment of pancreatic disease has recently been reported in adults. However, its application in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) in children is limited. In this article, we report single incision laparoscopic 90 % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. Between July 2011 and February 2015, the single incision laparoscopic 90 % pancreatectomy was performed in three children with PHHI. All patients underwent 18F-FDOPA PET/CT before the surgeries. The scans showed diffuse physiologic 18F-FDOPA activity in entire pancreas. All patients were followed up. The levels of blood sugar and insulin were recorded postoperatively. The time required for surgery was 120–230 min, and blood loss was minimal. The hospital stay was 6 days. The duration of postoperative abdominal drainage was 4–5 days. The levels of fasting blood glucose after surgery were higher than those before surgery (4.38–8.9 vs. 0.54–1.8 mmol/L). The levels of fasting insulin after surgery were lower than those before surgery (2.4–5.5 vs. 14–33.3 uU/ml). The duration of follow-up was 4–46 months. During follow-up, the levels of blood glucose and insulin were normal in three patients. There was no recurrence of hypoglycemia after operation in all patients. Single incision laparoscopic 90 % pancreatectomy for children with PHHI is feasible and safe in well-selected cases in the experienced centers.

KW - Children

KW - Hyperinsulinemia

KW - Hypoglycemia

KW - SILS

UR - http://www.scopus.com/inward/record.url?scp=84980000607&partnerID=8YFLogxK

U2 - 10.1007/s00383-016-3943-9

DO - 10.1007/s00383-016-3943-9

M3 - Article

VL - 32

SP - 1003

EP - 1007

JO - Pediatric Surgery International

JF - Pediatric Surgery International

SN - 0179-0358

IS - 10

ER -