Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection

Jim Gerostamoulos; Kerryn Crump; Iain M. McIntyre; Olaf H. Drummer

doi:10.1016/0378-4347(93)80435-7

Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection

Jim Gerostamoulos, Kerryn Crump, Iain M. McIntyre, Olaf H. Drummer

Department of Forensic Medicine

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

A method is described for the simultaneous determination of 6-monoacetylmorphine (6-MAM), morphine and codeine in post-mortem urine specimens using reversed-phase high-performance liquid chromatography with dual ultraviolet spectrophotometric and electrochemical detection. The limits of detection for a 1-ml urine sample were 0.04 mg/l for 6-MAM and 0.05 mg/l for both morphine and codeine. The presence of 6-MAM in urine indicates prior use of heroin and enables differentiation between morphine- and heroin-related deaths.

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Journal of Chromatography B: Biomedical Sciences and Applications
Volume	617
Issue number	1
DOIs	https://doi.org/10.1016/0378-4347(93)80435-7
Publication status	Published - 23 Jul 1993

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Gerostamoulos, J., Crump, K., McIntyre, I. M., & Drummer, O. H. (1993). Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection. Journal of Chromatography B: Biomedical Sciences and Applications, 617(1), 152-156. https://doi.org/10.1016/0378-4347(93)80435-7

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abstract = "A method is described for the simultaneous determination of 6-monoacetylmorphine (6-MAM), morphine and codeine in post-mortem urine specimens using reversed-phase high-performance liquid chromatography with dual ultraviolet spectrophotometric and electrochemical detection. The limits of detection for a 1-ml urine sample were 0.04 mg/l for 6-MAM and 0.05 mg/l for both morphine and codeine. The presence of 6-MAM in urine indicates prior use of heroin and enables differentiation between morphine- and heroin-related deaths.",

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Gerostamoulos, J, Crump, K, McIntyre, IM & Drummer, OH 1993, 'Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 617, no. 1, pp. 152-156. https://doi.org/10.1016/0378-4347(93)80435-7

Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection. / Gerostamoulos, Jim; Crump, Kerryn; McIntyre, Iain M. et al.
In: Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 617, No. 1, 23.07.1993, p. 152-156.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection

AU - Gerostamoulos, Jim

AU - Crump, Kerryn

AU - McIntyre, Iain M.

AU - Drummer, Olaf H.

PY - 1993/7/23

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AB - A method is described for the simultaneous determination of 6-monoacetylmorphine (6-MAM), morphine and codeine in post-mortem urine specimens using reversed-phase high-performance liquid chromatography with dual ultraviolet spectrophotometric and electrochemical detection. The limits of detection for a 1-ml urine sample were 0.04 mg/l for 6-MAM and 0.05 mg/l for both morphine and codeine. The presence of 6-MAM in urine indicates prior use of heroin and enables differentiation between morphine- and heroin-related deaths.

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Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid chromatography with combined ultraviolet and electrochemical detection

Abstract

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