Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain

Sharna D. Jamadar, Phillip G.D. Ward, Thomas G. Close, Alex Fornito, Malin Premaratne, Kieran O’Brien, Daniel Stäb, Zhaolin Chen, N. Jon Shah, Gary F. Egan

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21 Citations (Scopus)


Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain – cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18–20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.

Original languageEnglish
Article number363
Number of pages12
JournalScientific Data
Issue number1
Publication statusPublished - 21 Oct 2020


  • network models
  • neural circuits

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