Simulation sudy of the TNFα mediated NF-κB signaling pathway

Kwang Hyun Cho, Sung Young Shin, Hyeon Woo Lee, Olaf Wolkenhauer

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Abstract

Tumor necrosis factor α (TNFα) is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNFα mediated NF-κB signaling pathway based on a system-theoretic approach. Up to the present, there have been numerous approaches to analyze and model cellular dynamics. The most prominent one is utilizing nonlinear differential equations to establish a mathematical model based on reaction kinetics. This approach can provide us with mathematically well-founded and tractable interpretations regarding pathways, especially those best described by enzyme reactions. This paper introduces not only an intuitive graphical model but also a quantitative mathematical model for the TNFα mediated NF-κB signaling pathway. Throughout simulation study, we can qualitatively validate the developed mathematical model compared with experimental results along this pathway. Further investigations into the TNFα mediated NF-κB signaling pathway are in progress to include an inhibitor kinase functioning in this pathway.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
EditorsCorrado Priami
PublisherSpringer-Verlag London Ltd.
Number of pages1
ISBN (Print)3540006052, 9783540006053
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes
Event1st International Workshop on Computational Methods in Systems Biology, CMSB 2003 - Rovereto, Italy
Duration: 24 Feb 200326 Feb 2003

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume2602
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Computational Methods in Systems Biology, CMSB 2003
CountryItaly
CityRovereto
Period24/02/0326/02/03

Cite this

Cho, K. H., Shin, S. Y., Lee, H. W., & Wolkenhauer, O. (2003). Simulation sudy of the TNFα mediated NF-κB signaling pathway. In C. Priami (Ed.), Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 2602). Springer-Verlag London Ltd.. https://doi.org/10.1007/3-540-36481-1_20