Simulation of in vivo irreversible electroporation renal ablations

Robert E. Neal; Paulo A. Garcia; Helen Kavnoudias; Franklin Rosenfeldt; Catriona A. McLean; Victoria Earl; Joanne Bergman; Rafael V. Davalos; Kenneth R. Thomson

doi:10.1007/978-3-319-11128-5_202

Simulation of in vivo irreversible electroporation renal ablations

Robert E. Neal, Paulo A. Garcia, Helen Kavnoudias, Franklin Rosenfeldt, Catriona A. McLean, Victoria Earl, Joanne Bergman, Rafael V. Davalos, Kenneth R. Thomson

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

8 Citations (Scopus)

Abstract

Irreversible electroporation (IRE) uses brief electric pulses to irrecoverably disrupt cell membranes, leading to cell death in a volume of tissue while leaving proteins and the extracellular matrix intact. This enables ablation without damaging blood vessels, ductal systems, and other sensitive structures. IRE has numerous indications, yet clear determination of effective lethal electric field thresholds for a number of tissues remains. In the presented work, a clinically relevant IRE electric pulse protocol is used to create focal renal ablations in canines while measuring electrical currents. Electrical data and resulting acute lesions are used to calibrate numerical models, which determined an electric field threshold of 506 V/cm (range 485 to 526 V/cm) that kills healthy renal tissue when applying a pulsing protocol of one hundred, 100 μs long pulses at a rate of one pulse per second.

Original language	English
Title of host publication	6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014
Editors	Igor Lackovic, Darko Vasic
Place of Publication	Switzerland
Publisher	Springer
Pages	813-816
Number of pages	4
ISBN (Electronic)	9783319111278
DOIs	https://doi.org/10.1007/978-3-319-11128-5_202
Publication status	Published - 2015
Externally published	Yes
Event	European Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014 - Dubrovnik, Croatia Duration: 7 Sept 2014 → 11 Sept 2014 Conference number: 6th

Publication series

Name	IFMBE Proceedings
Volume	45
ISSN (Print)	1680-0737

Conference

Conference	European Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014
Abbreviated title	MBEC 2014
Country/Territory	Croatia
City	Dubrovnik
Period	7/09/14 → 11/09/14

Keywords

Electric field calibration
Kidney tumors
Minimally invasive surgery
Numerical models
Renal cell carcinoma

Access to Document

10.1007/978-3-319-11128-5_202

Cite this

Neal, R. E., Garcia, P. A., Kavnoudias, H., Rosenfeldt, F., McLean, C. A., Earl, V., Bergman, J., Davalos, R. V., & Thomson, K. R. (2015). Simulation of in vivo irreversible electroporation renal ablations. In I. Lackovic, & D. Vasic (Eds.), 6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014 (pp. 813-816). (IFMBE Proceedings; Vol. 45). Springer. https://doi.org/10.1007/978-3-319-11128-5_202

@inproceedings{ae070c8d33d44dcaa9b2eab9af7041d3,

title = "Simulation of in vivo irreversible electroporation renal ablations",

abstract = "Irreversible electroporation (IRE) uses brief electric pulses to irrecoverably disrupt cell membranes, leading to cell death in a volume of tissue while leaving proteins and the extracellular matrix intact. This enables ablation without damaging blood vessels, ductal systems, and other sensitive structures. IRE has numerous indications, yet clear determination of effective lethal electric field thresholds for a number of tissues remains. In the presented work, a clinically relevant IRE electric pulse protocol is used to create focal renal ablations in canines while measuring electrical currents. Electrical data and resulting acute lesions are used to calibrate numerical models, which determined an electric field threshold of 506 V/cm (range 485 to 526 V/cm) that kills healthy renal tissue when applying a pulsing protocol of one hundred, 100 μs long pulses at a rate of one pulse per second.",

keywords = "Electric field calibration, Kidney tumors, Minimally invasive surgery, Numerical models, Renal cell carcinoma",

author = "Neal, {Robert E.} and Garcia, {Paulo A.} and Helen Kavnoudias and Franklin Rosenfeldt and McLean, {Catriona A.} and Victoria Earl and Joanne Bergman and Davalos, {Rafael V.} and Thomson, {Kenneth R.}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; European Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014, MBEC 2014 ; Conference date: 07-09-2014 Through 11-09-2014",

year = "2015",

doi = "10.1007/978-3-319-11128-5_202",

language = "English",

series = "IFMBE Proceedings",

publisher = "Springer",

pages = "813--816",

editor = "Igor Lackovic and Darko Vasic",

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}

Neal, RE, Garcia, PA, Kavnoudias, H, Rosenfeldt, F, McLean, CA, Earl, V, Bergman, J, Davalos, RV & Thomson, KR 2015, Simulation of in vivo irreversible electroporation renal ablations. in I Lackovic & D Vasic (eds), 6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014. IFMBE Proceedings, vol. 45, Springer, Switzerland, pp. 813-816, European Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014, Dubrovnik, Croatia, 7/09/14. https://doi.org/10.1007/978-3-319-11128-5_202

Simulation of in vivo irreversible electroporation renal ablations. / Neal, Robert E.; Garcia, Paulo A.; Kavnoudias, Helen et al.
6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014. ed. / Igor Lackovic; Darko Vasic. Switzerland: Springer, 2015. p. 813-816 (IFMBE Proceedings; Vol. 45).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Simulation of in vivo irreversible electroporation renal ablations

AU - Neal, Robert E.

AU - Garcia, Paulo A.

AU - Kavnoudias, Helen

AU - Rosenfeldt, Franklin

AU - McLean, Catriona A.

AU - Earl, Victoria

AU - Bergman, Joanne

AU - Davalos, Rafael V.

AU - Thomson, Kenneth R.

N1 - Conference code: 6th

PY - 2015

Y1 - 2015

N2 - Irreversible electroporation (IRE) uses brief electric pulses to irrecoverably disrupt cell membranes, leading to cell death in a volume of tissue while leaving proteins and the extracellular matrix intact. This enables ablation without damaging blood vessels, ductal systems, and other sensitive structures. IRE has numerous indications, yet clear determination of effective lethal electric field thresholds for a number of tissues remains. In the presented work, a clinically relevant IRE electric pulse protocol is used to create focal renal ablations in canines while measuring electrical currents. Electrical data and resulting acute lesions are used to calibrate numerical models, which determined an electric field threshold of 506 V/cm (range 485 to 526 V/cm) that kills healthy renal tissue when applying a pulsing protocol of one hundred, 100 μs long pulses at a rate of one pulse per second.

AB - Irreversible electroporation (IRE) uses brief electric pulses to irrecoverably disrupt cell membranes, leading to cell death in a volume of tissue while leaving proteins and the extracellular matrix intact. This enables ablation without damaging blood vessels, ductal systems, and other sensitive structures. IRE has numerous indications, yet clear determination of effective lethal electric field thresholds for a number of tissues remains. In the presented work, a clinically relevant IRE electric pulse protocol is used to create focal renal ablations in canines while measuring electrical currents. Electrical data and resulting acute lesions are used to calibrate numerical models, which determined an electric field threshold of 506 V/cm (range 485 to 526 V/cm) that kills healthy renal tissue when applying a pulsing protocol of one hundred, 100 μs long pulses at a rate of one pulse per second.

KW - Electric field calibration

KW - Kidney tumors

KW - Minimally invasive surgery

KW - Numerical models

KW - Renal cell carcinoma

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AN - SCOPUS:84937804808

T3 - IFMBE Proceedings

SP - 813

EP - 816

BT - 6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014

A2 - Lackovic, Igor

A2 - Vasic, Darko

PB - Springer

CY - Switzerland

T2 - European Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014

Y2 - 7 September 2014 through 11 September 2014

ER -

Neal RE, Garcia PA, Kavnoudias H, Rosenfeldt F, McLean CA, Earl V et al. Simulation of in vivo irreversible electroporation renal ablations. In Lackovic I, Vasic D, editors, 6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014. Switzerland: Springer. 2015. p. 813-816. (IFMBE Proceedings). doi: 10.1007/978-3-319-11128-5_202

Simulation of in vivo irreversible electroporation renal ablations

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Keywords

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