Simulation of in vivo irreversible electroporation renal ablations

Robert E. Neal, Paulo A. Garcia, Helen Kavnoudias, Franklin Rosenfeldt, Catriona A. McLean, Victoria Earl, Joanne Bergman, Rafael V. Davalos, Kenneth R. Thomson

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

7 Citations (Scopus)

Abstract

Irreversible electroporation (IRE) uses brief electric pulses to irrecoverably disrupt cell membranes, leading to cell death in a volume of tissue while leaving proteins and the extracellular matrix intact. This enables ablation without damaging blood vessels, ductal systems, and other sensitive structures. IRE has numerous indications, yet clear determination of effective lethal electric field thresholds for a number of tissues remains. In the presented work, a clinically relevant IRE electric pulse protocol is used to create focal renal ablations in canines while measuring electrical currents. Electrical data and resulting acute lesions are used to calibrate numerical models, which determined an electric field threshold of 506 V/cm (range 485 to 526 V/cm) that kills healthy renal tissue when applying a pulsing protocol of one hundred, 100 μs long pulses at a rate of one pulse per second.

Original languageEnglish
Title of host publication6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014
EditorsIgor Lackovic, Darko Vasic
Place of PublicationSwitzerland
PublisherSpringer
Pages813-816
Number of pages4
ISBN (Electronic)9783319111278
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventEuropean Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014 - Dubrovnik, Croatia
Duration: 7 Sept 201411 Sept 2014
Conference number: 6th

Publication series

NameIFMBE Proceedings
Volume45
ISSN (Print)1680-0737

Conference

ConferenceEuropean Conference of the International-Federation-for-Medical-and-Biological-Engineering (MBEC) 2014
Abbreviated titleMBEC 2014
Country/TerritoryCroatia
CityDubrovnik
Period7/09/1411/09/14

Keywords

  • Electric field calibration
  • Kidney tumors
  • Minimally invasive surgery
  • Numerical models
  • Renal cell carcinoma

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