Simulated dynamic interaction of coupled sinoatrial node pacemaker cells pairs

S. Cloherty, N. Lovell, B. Celler, S. Dokos

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Abstract

Previous modelling studies by other investigators indicates that electronic coupling between cells underlies mutual entrainment and synchronization of the intact sinus node. In this study, interaction between a pair of resistively coupled pacemaker cells was investigated using a complex, physiologically accurate model of the single sinoatrial node cell. Variation in intrinsic cycle length was achieved by multiplying the background sodium conductance gb,Na by a constant modulating parameter (0 < α ≤ 1.0). For each value of the modulating parameter a single cell was integrated until a steady state was achieved, at which point the model parameters were saved for use as initial conditions in the simulations of coupled cells pairs. The effect of cycle length and magnitude of coupling resistance on entrainment were investigated. Simulation results are presented demonstrating both simple and complex entrainment phenomena.

Original languageEnglish
Title of host publication22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2000
Pages395-397
Number of pages3
Volume1
Publication statusPublished - 1 Dec 2000
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2000 - Chicago, United States of America
Duration: 23 Jul 200028 Jul 2000
Conference number: 22nd
https://ieeexplore.ieee.org/xpl/conhome/7218/proceeding?isnumber=19483 (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2000
Abbreviated titleEMBC 2000
CountryUnited States of America
CityChicago
Period23/07/0028/07/00
Internet address

Keywords

  • Dynamic interaction
  • Modeling
  • Mutual entrainment
  • Sinoatrial node

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