Simplified platensimycin analogues as antibacterial agents

Dragan Krsta, Ka Uen Caron Ku, Ian Travers Crosby, Benvenuto Capuano, David Thomas Manallack

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Abstract

A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.
Original languageEnglish
Pages (from-to)244 - 249
Number of pages6
JournalMedChemComm
Volume3
Issue number2
DOIs
Publication statusPublished - 2012

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