Simplified platensimycin analogues as antibacterial agents

Dragan Krsta; Ka Uen Caron Ku; Ian Travers Crosby; Benvenuto Capuano; David Thomas Manallack

doi:10.1039/c2md00252c

Simplified platensimycin analogues as antibacterial agents

Dragan Krsta, Ka Uen Caron Ku, Ian Travers Crosby, Benvenuto Capuano, David Thomas Manallack

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.

Original language	English
Pages (from-to)	244 - 249
Number of pages	6
Journal	MedChemComm
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/c2md00252c
Publication status	Published - 2012

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10.1039/c2md00252c

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title = "Simplified platensimycin analogues as antibacterial agents",

abstract = "A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.",

author = "Dragan Krsta and Ku, {Ka Uen Caron} and Crosby, {Ian Travers} and Benvenuto Capuano and Manallack, {David Thomas}",

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AU - Crosby, Ian Travers

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AU - Manallack, David Thomas

PY - 2012

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AB - A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.

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DO - 10.1039/c2md00252c

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JO - MedChemComm

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Simplified platensimycin analogues as antibacterial agents

Abstract

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