Similarities of Giardia antigens derived from human and animal sources

A. G. Capon, J. A. Upcroft, P. F.L. Boreham, L. E. Cottis, P. G. Bundesen

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44 Citations (Scopus)

Abstract

Similarities of Giardia antigens derived from human and animal sources. International Journal for Parasitology 19: 91-98. A total of 37 Giardia stocks isolated from humans and 14 stocks derived from animal sources have been analysed for antigenic differences. Separation of the proteins of the stocks by polyacrylamide gel electrophoresis showed no major differences among the stocks. Immunoblotting of these antigens demonstrated some minor differences which were not correlated with geographic location, allozyme type, virulence or any other distinguishing characteristic of the stocks. Immunofluorescence tests using monoclonal antibodies revealed some differences between stocks but the monoclonal antibodies did not significantly inhibit growth in inhibition assays.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalInternational Journal for Parasitology
Volume19
Issue number1
DOIs
Publication statusPublished - Feb 1989
Externally publishedYes

Keywords

  • antigens
  • Giardia
  • growth inhibition
  • immunoblotting
  • immunofluorescence
  • PAGE

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