Silver-catalyzed tandem hydroamination/hydroarylation of 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones to 1 '-allylspiro[indene-1,2 '-indolin]-3 '-ones

An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1′- allylspiro[indene-1,2′-indolin]-3′-ones from 1-(2-allylamino)- phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly functionalized spiro-targets in high yield. This novel class of molecule possesses both the privileged indene and indolin-3- one scaffold, which may lead to possible pharmacological applications.