Abstract
An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1′- allylspiro[indene-1,2′-indolin]-3′-ones from 1-(2-allylamino)- phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly functionalized spiro-targets in high yield. This novel class of molecule possesses both the privileged indene and indolin-3- one scaffold, which may lead to possible pharmacological applications.
Original language | English |
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Pages (from-to) | 4110 - 4113 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Keywords
- Gold
- gold catalysis
- Catalysis