Silica Nanopills for Targeted Anticancer Drug Delivery

Maria Alba Martin, Bahman Delalat, Pilar Formentín, Mary Louise Rogers, Lluís F. Marsal, Nicolas H. Voelcker

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.

Original languageEnglish
Pages (from-to)4626-4631
Number of pages6
JournalSmall
Volume11
Issue number36
DOIs
Publication statusPublished - 23 Sep 2015
Externally publishedYes

Keywords

  • antibodies
  • cancer therapy
  • drug delivery
  • microtubes
  • porous silicon

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