Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

Bianca C Bernardo, Xiao-Ming Gao, Yow Keat Tham, Helen Kiriazis, Catherine E Winbanks, Jenny Ying Ying Ooi, Esther J H Boey, Susanna Obad, Sakari Kauppinen, Paul Gregorevic, Xiao-Jun Du, Ruby C Y Lin, Julie Rae McMullen

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Abstract

The aim of this study was to assess whether inhibition of miR-34a could attenuate cardiac remodeling in a mouse model with pre-existing pathological hypertrophy.
Original languageEnglish
Article numbere90337
Number of pages13
JournalPLoS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 2014

Cite this

Bernardo, B. C., Gao, X-M., Tham, Y. K., Kiriazis, H., Winbanks, C. E., Ooi, J. Y. Y., Boey, E. J. H., Obad, S., Kauppinen, S., Gregorevic, P., Du, X-J., Lin, R. C. Y., & McMullen, J. R. (2014). Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy. PLoS ONE, 9(2), [e90337]. https://doi.org/10.1371/journal.pone.0090337