Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer

Samar Masoumi Moghaddam, Afshin Amini, David L. Morris, Mohammad H. Pourgholami

Research output: Contribution to journalReview ArticleResearchpeer-review

128 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis which drives endothelial cell survival, proliferation, and migration while increasing vascular permeability. Playing an important role in the physiology of normal ovaries, VEGF has also been implicated in the pathogenesis of ovarian cancer. Essentially by promoting tumor angiogenesis and enhancing vascular permeability, VEGF contributes to the development of peritoneal carcinomatosis associated with malignant ascites formation, the characteristic feature of advanced ovarian cancer at diagnosis. In both experimental and clinical studies, VEGF levels have been inversely correlated with survival. Moreover, VEGF inhibition has been shown to inhibit tumor growth and ascites production and to suppress tumor invasion and metastasis. These findings have laid the basis for the clinical evaluation of agents targeting VEGF signaling pathway in patients with ovarian cancer. In this review, we will focus on VEGF involvement in the pathophysiology of ovarian cancer and its contribution to the disease progression and dissemination.

Original languageEnglish
Pages (from-to)143-162
Number of pages20
JournalCancer and Metastasis Reviews
Volume31
Issue number1-2
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

Keywords

  • Angiogenesis
  • Bevacizumab
  • Malignant ascites
  • Ovarian cancer
  • Peritoneal carcinomatosis
  • Vascular endothelial growth factor

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