Signaling to the ribosome in cancer - It is more than just mTORC1

Katherine M Hannan, Elaine Sanij, Nadine Hein, Ross Duncan Hannan, Richard B Pearson

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

It is becoming increasingly clear that dysregulation of protein synthesis contributes to a range of diseases characterized by tissue overgrowth. These include arterial stenosis, cardiac hypertrophy, hamartomas, and cancer. The central hub for the regulation of protein synthesis is the ribosome, where the key signaling pathways downstream of RAS, MYC, and phosphatidylinositol-3-kinase (PI3K) converge to confer exquisite, coordinated control of ribosome synthesis and function. Such cooperation ensures strict regulation of protein synthesis rates and cell growth. This review will focus on the role the PI3K/AKT/mammalian target of rapamycin complex 1 (mTORC1) pathway plays in regulating ribosome function during both health and disease, its interaction with the other key growth regulatory pathways activated by RAS and MYC, and the therapeutic potential for targeting this network.
Original languageEnglish
Pages (from-to)79 - 85
Number of pages7
JournalIUBMB Life
Volume63
Issue number2
DOIs
Publication statusPublished - 2011

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