Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

Sam E. John, Nicholas L. Opie, Yan T. Wong, Gil S. Rind, Stephen M. Ronayne, Giulia Gerboni, Sebastien H. Bauquier, Terence J. O'Brien, Clive N. May, David B. Grayden, Thomas J. Oxley

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. However, the effect of the dura and blood vessel on recording signal quality is not understood and may be a critical factor impacting implementation of a closed-loop endovascular neuromodulation system. The present work compares the performance and recording signal quality of a minimally-invasive endovascular neural interface with conventional subdural and epidural interfaces. We compared bandwidth, signal-to-noise ratio, and spatial resolution of recorded cortical signals using subdural, epidural and endovascular arrays four weeks after implantation in sheep. We show that the quality of the signals (bandwidth and signal-to-noise ratio) of the endovascular neural interface is not significantly different from conventional neural sensors. However, the spatial resolution depends on the array location and the frequency of recording. We also show that there is a direct correlation between the signal-noise-ratio and classification accuracy, and that decoding accuracy is comparable between electrode arrays. These results support the consideration for use of an endovascular neural interface in a clinical trial of a novel closed-loop neuromodulation technology.

Original languageEnglish
Article number8427
Number of pages12
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

Cite this

John, Sam E. ; Opie, Nicholas L. ; Wong, Yan T. ; Rind, Gil S. ; Ronayne, Stephen M. ; Gerboni, Giulia ; Bauquier, Sebastien H. ; O'Brien, Terence J. ; May, Clive N. ; Grayden, David B. ; Oxley, Thomas J. / Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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title = "Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable",
abstract = "Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. However, the effect of the dura and blood vessel on recording signal quality is not understood and may be a critical factor impacting implementation of a closed-loop endovascular neuromodulation system. The present work compares the performance and recording signal quality of a minimally-invasive endovascular neural interface with conventional subdural and epidural interfaces. We compared bandwidth, signal-to-noise ratio, and spatial resolution of recorded cortical signals using subdural, epidural and endovascular arrays four weeks after implantation in sheep. We show that the quality of the signals (bandwidth and signal-to-noise ratio) of the endovascular neural interface is not significantly different from conventional neural sensors. However, the spatial resolution depends on the array location and the frequency of recording. We also show that there is a direct correlation between the signal-noise-ratio and classification accuracy, and that decoding accuracy is comparable between electrode arrays. These results support the consideration for use of an endovascular neural interface in a clinical trial of a novel closed-loop neuromodulation technology.",
author = "John, {Sam E.} and Opie, {Nicholas L.} and Wong, {Yan T.} and Rind, {Gil S.} and Ronayne, {Stephen M.} and Giulia Gerboni and Bauquier, {Sebastien H.} and O'Brien, {Terence J.} and May, {Clive N.} and Grayden, {David B.} and Oxley, {Thomas J.}",
year = "2018",
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John, SE, Opie, NL, Wong, YT, Rind, GS, Ronayne, SM, Gerboni, G, Bauquier, SH, O'Brien, TJ, May, CN, Grayden, DB & Oxley, TJ 2018, 'Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable' Scientific Reports, vol. 8, no. 1, 8427. https://doi.org/10.1038/s41598-018-26457-7

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable. / John, Sam E.; Opie, Nicholas L.; Wong, Yan T.; Rind, Gil S.; Ronayne, Stephen M.; Gerboni, Giulia; Bauquier, Sebastien H.; O'Brien, Terence J.; May, Clive N.; Grayden, David B.; Oxley, Thomas J.

In: Scientific Reports, Vol. 8, No. 1, 8427, 01.12.2018.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Gerboni, Giulia

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