Shutting the gate: targeting endocytosis in acute leukemia

Cedric S. Tremblay, Stephen B. Ting, Adam McCluskey, Phillip J. Robinson, David J. Curtis

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Endocytosis entails selective packaging of cell surface cargos in cytoplasmic vesicles, thereby controlling key intrinsic cellular processes as well as the response of normal and malignant cells to their microenvironment. The purpose of this review is to outline the latest advances in the development of endocytosis-targeting therapeutic strategies in hematological malignancies.

Original languageEnglish
Pages (from-to)17-31
Number of pages15
JournalExperimental Hematology
Volume104
DOIs
Publication statusPublished - Dec 2021

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