Should female partners of men with non-gonococcal urethritis, negative for Chlamydia trachomatis and Mycoplasma genitalium, be informed and treated? Clinical outcomes from a partner study of heterosexual men with NGU

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Abstract

Background: To determine if female partners of men with pathogennegative non-gonococcal urethritis (NGU) are at risk of genital infection. Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic inMelbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. trachomatis (n = 176); 3) men with urethral M. genitalium (n = 26); and 4) asymptomatic men (n = 652). Results: Female partners of men with pathogen-negative NGU experienced deep pelvic pain (adjusted odds ratio [AOR], 2.2; 95% confidence interval [CI], 1.1-4.4), post coital bleeding (AOR, 2.4; 95% CI, 1.2-4.9), and dysuria (AOR, 3.7; 95% CI, 1.6-8.6) more commonly and were diagnosed with PID more commonly (AOR, 4.8; 95% CI, 2.1-11.3) than the female partners of asymptomatic men. Pelvic inflammatory disease was not more likely to be diagnosed in the female partners ofmen with genitalwarts (AOR, 1.4; 95% CI, 0.5-4.4) or candidiasis (AOR, 1.2; 95% CI, 0.4-3.5) than the female partners of asymptomatic men. The female partners of men with chlamydia experienced post coital bleeding more (AOR, 1.9; 95% CI, 1.0-3.6) and were more likely to be diagnosed with PID (AOR, 3.6; 95% CI, 1.6-8.0). Conclusions: The female partners of men with pathogen-negative NGU may be at increased risk of genital infection, even if a recognised pathogen is not identified in the man.

Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalSexually Transmitted Diseases
Volume44
Issue number2
DOIs
Publication statusPublished - 2017

Cite this

@article{d4982c2096504ff39e1fd402df44e28e,
title = "Should female partners of men with non-gonococcal urethritis, negative for Chlamydia trachomatis and Mycoplasma genitalium, be informed and treated? Clinical outcomes from a partner study of heterosexual men with NGU",
abstract = "Background: To determine if female partners of men with pathogennegative non-gonococcal urethritis (NGU) are at risk of genital infection. Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic inMelbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. trachomatis (n = 176); 3) men with urethral M. genitalium (n = 26); and 4) asymptomatic men (n = 652). Results: Female partners of men with pathogen-negative NGU experienced deep pelvic pain (adjusted odds ratio [AOR], 2.2; 95{\%} confidence interval [CI], 1.1-4.4), post coital bleeding (AOR, 2.4; 95{\%} CI, 1.2-4.9), and dysuria (AOR, 3.7; 95{\%} CI, 1.6-8.6) more commonly and were diagnosed with PID more commonly (AOR, 4.8; 95{\%} CI, 2.1-11.3) than the female partners of asymptomatic men. Pelvic inflammatory disease was not more likely to be diagnosed in the female partners ofmen with genitalwarts (AOR, 1.4; 95{\%} CI, 0.5-4.4) or candidiasis (AOR, 1.2; 95{\%} CI, 0.4-3.5) than the female partners of asymptomatic men. The female partners of men with chlamydia experienced post coital bleeding more (AOR, 1.9; 95{\%} CI, 1.0-3.6) and were more likely to be diagnosed with PID (AOR, 3.6; 95{\%} CI, 1.6-8.0). Conclusions: The female partners of men with pathogen-negative NGU may be at increased risk of genital infection, even if a recognised pathogen is not identified in the man.",
author = "Ong, {Jason J.} and Angela Sarumpaet and Chow, {Eric P. F.} and Catriona Bradshaw and Marcus Chen and Tim Read and Fairley, {Christopher K.}",
year = "2017",
doi = "10.1097/OLQ.0000000000000546",
language = "English",
volume = "44",
pages = "126--130",
journal = "Sexually Transmitted Diseases",
issn = "0148-5717",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

TY - JOUR

T1 - Should female partners of men with non-gonococcal urethritis, negative for Chlamydia trachomatis and Mycoplasma genitalium, be informed and treated? Clinical outcomes from a partner study of heterosexual men with NGU

AU - Ong, Jason J.

AU - Sarumpaet, Angela

AU - Chow, Eric P. F.

AU - Bradshaw, Catriona

AU - Chen, Marcus

AU - Read, Tim

AU - Fairley, Christopher K.

PY - 2017

Y1 - 2017

N2 - Background: To determine if female partners of men with pathogennegative non-gonococcal urethritis (NGU) are at risk of genital infection. Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic inMelbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. trachomatis (n = 176); 3) men with urethral M. genitalium (n = 26); and 4) asymptomatic men (n = 652). Results: Female partners of men with pathogen-negative NGU experienced deep pelvic pain (adjusted odds ratio [AOR], 2.2; 95% confidence interval [CI], 1.1-4.4), post coital bleeding (AOR, 2.4; 95% CI, 1.2-4.9), and dysuria (AOR, 3.7; 95% CI, 1.6-8.6) more commonly and were diagnosed with PID more commonly (AOR, 4.8; 95% CI, 2.1-11.3) than the female partners of asymptomatic men. Pelvic inflammatory disease was not more likely to be diagnosed in the female partners ofmen with genitalwarts (AOR, 1.4; 95% CI, 0.5-4.4) or candidiasis (AOR, 1.2; 95% CI, 0.4-3.5) than the female partners of asymptomatic men. The female partners of men with chlamydia experienced post coital bleeding more (AOR, 1.9; 95% CI, 1.0-3.6) and were more likely to be diagnosed with PID (AOR, 3.6; 95% CI, 1.6-8.0). Conclusions: The female partners of men with pathogen-negative NGU may be at increased risk of genital infection, even if a recognised pathogen is not identified in the man.

AB - Background: To determine if female partners of men with pathogennegative non-gonococcal urethritis (NGU) are at risk of genital infection. Methods: Secondary data analysis using health records from a large sexually transmitted disease clinic inMelbourne of 1710 men and their female partners attending on the same day from January 2006 to April 2015. Proportions of female partners with symptoms suggesting genital infection or pelvic inflammatory disease (PID) were determined for: (1) men with NGU and no Chlamydia trachomatis or Mycoplasma genitalium (referred to as pathogen-negative NGU) (n = 91); 2) men with urethral C. trachomatis (n = 176); 3) men with urethral M. genitalium (n = 26); and 4) asymptomatic men (n = 652). Results: Female partners of men with pathogen-negative NGU experienced deep pelvic pain (adjusted odds ratio [AOR], 2.2; 95% confidence interval [CI], 1.1-4.4), post coital bleeding (AOR, 2.4; 95% CI, 1.2-4.9), and dysuria (AOR, 3.7; 95% CI, 1.6-8.6) more commonly and were diagnosed with PID more commonly (AOR, 4.8; 95% CI, 2.1-11.3) than the female partners of asymptomatic men. Pelvic inflammatory disease was not more likely to be diagnosed in the female partners ofmen with genitalwarts (AOR, 1.4; 95% CI, 0.5-4.4) or candidiasis (AOR, 1.2; 95% CI, 0.4-3.5) than the female partners of asymptomatic men. The female partners of men with chlamydia experienced post coital bleeding more (AOR, 1.9; 95% CI, 1.0-3.6) and were more likely to be diagnosed with PID (AOR, 3.6; 95% CI, 1.6-8.0). Conclusions: The female partners of men with pathogen-negative NGU may be at increased risk of genital infection, even if a recognised pathogen is not identified in the man.

UR - http://www.scopus.com/inward/record.url?scp=85010041705&partnerID=8YFLogxK

U2 - 10.1097/OLQ.0000000000000546

DO - 10.1097/OLQ.0000000000000546

M3 - Article

VL - 44

SP - 126

EP - 130

JO - Sexually Transmitted Diseases

JF - Sexually Transmitted Diseases

SN - 0148-5717

IS - 2

ER -