Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

C. Chapman; N. Tubridy; M. J. Cook; P. J. Mitchell; L. R. MacGregor; C. Lovelock; L. Litewka; L. Sedal; T. J. Kilpatrick; H. Butzkueven

doi:10.1016/j.jocn.2005.08.012

Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

C. Chapman, N. Tubridy, M. J. Cook, P. J. Mitchell, L. R. MacGregor, C. Lovelock, L. Litewka, L. Sedal, T. J. Kilpatrick, H. Butzkueven

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.

Original language	English
Pages (from-to)	636-638
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.jocn.2005.08.012
Publication status	Published - 1 Jul 2006
Externally published	Yes

Keywords

Cerebral atrophy
Cerebral volume
Methylprednisolone
Multiple sclerosis

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10.1016/j.jocn.2005.08.012

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title = "Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses",

abstract = "We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.",

keywords = "Cerebral atrophy, Cerebral volume, Methylprednisolone, Multiple sclerosis",

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AU - Chapman, C.

AU - Tubridy, N.

AU - Cook, M. J.

AU - Mitchell, P. J.

AU - MacGregor, L. R.

AU - Lovelock, C.

AU - Litewka, L.

AU - Sedal, L.

AU - Kilpatrick, T. J.

AU - Butzkueven, H.

PY - 2006/7/1

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N2 - We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.

AB - We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.

KW - Cerebral atrophy

KW - Cerebral volume

KW - Methylprednisolone

KW - Multiple sclerosis

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JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

IS - 6

ER -

Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

Abstract

Keywords

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