Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Kevin J. Selva, Jennifer A. Juno, Matthew J. Worley, Amy W. Chung, Gilda Tachedjian, Stephen J. Kent, Matthew S. Parsons

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume35
Issue number6
DOIs
Publication statusPublished - 4 Jun 2019

Keywords

  • antibodies
  • Fc receptors
  • granulocytes
  • HIV-1
  • monocytes
  • semen

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