Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Kevin J. Selva; Jennifer A. Juno; Matthew J. Worley; Amy W. Chung; Gilda Tachedjian; Stephen J. Kent; Matthew S. Parsons

doi:10.1089/aid.2018.0219

Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Kevin J. Selva, Jennifer A. Juno, Matthew J. Worley, Amy W. Chung, Gilda Tachedjian, Stephen J. Kent, Matthew S. Parsons

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.

Original language	English
Pages (from-to)	553-556
Number of pages	4
Journal	AIDS Research and Human Retroviruses
Volume	35
Issue number	6
DOIs	https://doi.org/10.1089/aid.2018.0219
Publication status	Published - 4 Jun 2019

Keywords

antibodies
Fc receptors
granulocytes
HIV-1
monocytes
semen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/aid.2018.0219

Cite this

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title = "Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes",

abstract = "Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.",

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year = "2019",

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AU - Selva, Kevin J.

AU - Juno, Jennifer A.

AU - Worley, Matthew J.

AU - Chung, Amy W.

AU - Tachedjian, Gilda

AU - Kent, Stephen J.

AU - Parsons, Matthew S.

PY - 2019/6/4

Y1 - 2019/6/4

N2 - Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.

AB - Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.

KW - antibodies

KW - Fc receptors

KW - granulocytes

KW - HIV-1

KW - monocytes

KW - semen

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DO - 10.1089/aid.2018.0219

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AN - SCOPUS:85066977403

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SP - 553

EP - 556

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 6

ER -

Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Abstract

Keywords

UN SDGs

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this

Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this