It is shown that recently discovered haemodynamic waves can form shocklike fronts when driven by stimuli that excite the cortex in a patch that moves faster than the haemodynamic wave velocity. If stimuli are chosen in order to induce shock-like behaviour, the resulting blood oxygen level-dependent (BOLD) response is enhanced, thereby improving the signal to noise ratio of measurements made with functional magnetic resonance imaging. A spatiotemporal haemodynamic model is extended to calculate the BOLD response and determine the main properties of waves induced by moving stimuli. From this, the optimal conditions for stimulating shock-like responses are determined, and ways of inducing these responses in experiments are demonstrated in a pilot study.
|Number of pages||15|
|Journal||Journal of the Royal Society Interface|
|Publication status||Published - 31 Dec 2016|
- Blood oxygen level dependent (BOLD)
- Functional magnetic resonance imaging