Sheepish B cells: Evidence for antigen-independent antibody diversification in humans and mice

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10 Citations (Scopus)


Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigendriven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.

Original languageEnglish
Pages (from-to)1251-1254
Number of pages4
JournalJournal of Experimental Medicine
Issue number6
Publication statusPublished - 9 Jun 2008
Externally publishedYes

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