@article{af5dcab309894650a238121c147808e1,
title = "Shared signature of recent positive selection on the TSBP1–BTNL2–HLA-DRA genes in five native populations from north Borneo",
abstract = "North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of ~2.2 million genome-wide single nucleotide polymorphisms. As a result, an ~13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1–BTNL2–HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB populations and is estimated to have arisen ~5.5 thousand years (~220 generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment.",
keywords = "BTNL2, HLA-DRA, Malaria, Natural selection, North Borneo, TSBP1",
author = "Hoh, {Boon Peng} and Xiaoxi Zhang and Lian Deng and Kai Yuan and Yew, {Chee Wei} and Saw, {Woei Yuh} and Hoque, {Mohammad Zahirul} and Farhang Aghakhanian and Phipps, {Maude E.} and Teo, {Yik Ying} and Subbiah, {Vijay Kumar} and Shuhua Xu",
note = "Funding Information: This study was supported by the National Natural Science Foundation of China (NSFC) grant (31525014, 32030020, 91731303, 31771388, 31900418, 31961130380, and 32041008), the Strategic Priority Research Program (XDB38000000), and Key Research Program of Frontier Sciences (QYZDJ-SSW-SYS009) of the Chinese Academy of Sciences (CAS), the UK Royal Society-Newton Advanced Fellowship [NAF\R1\191094]; the National Key Research and Development Program [2016YFC0906403]; the Shanghai Municipal Science and Technology Major Project [2017SHZDZX01]; and the Science and Technology Commission of Shanghai Municipality [19YF1455200]. This project was funded by the National Biotechnology Division of the Ministry of Science, Technology and Innovation of Malaysia [project code: 100-RMI/BIOTEK 16/6/2B(1/2011)], and by the Ministry of Higher Education of Malaysia [Fundamental Research Grant Scheme, project code: FRG0449-STG-1/2016; and FRGS/1/2015/ST03/UCSI/01/1]. H.B.P acknowledges the Chinese Academy of Sciences President?s International Fellowship Initiatives [2017VBA0008] awarded to him. Y.Y.T. acknowledge support by the National Research Foundation, Prime Minister?s Office, Singapore under its Research Fellowship [NRF-RF-2010-05] and administered by the National University of Singapore. S.X. is Max-Planck Independent Research Group Leader and member of CAS Youth Innovation Promotion Association. S.X. also gratefully acknowledges the support of the National Program for Top-notch Young Innovative Talents of the ?Wanren Jihua? Project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} The Author(s) 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1093/GBE/EVAA207",
language = "English",
volume = "12",
pages = "2245--2257",
journal = "Genome Biology and Evolution",
issn = "1759-6653",
publisher = "Oxford University Press",
number = "12",
}