Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Paula Rovira; Ditte Demontis; Cristina Sanchez-Mora; Tetyana Zayats; Marieke Klein; Nina Roth Mota; Heike Weber; Iris Garcia-Martinez; Miriea Pagerols; Laura Vilar-Ribo; Lorena Arribas; Vanesa Richarte; Montserrat Corrales; Christian Fadeuilhe; Rosa Bosch; Gemma Espanol Martin; Peter Almos; Alysa E Doyle; Eugenio Horacio Grevet; Oliver Grimm; Anne Halmoy; Martine Hoogman; Mara Hutz; Christian Jacob; Sarah Kittel-Schneider; Per M Knappskog; Astri Johansen Lundervold; Olga Rivero; Diego Luiz Rovaris; Angelica Salatino-Oliveira; Bruna Santos da Silva; Evgeniy Svirin; Emma Sprooten; Tatyana Strekalova; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); 23andMe Research Team; Alejandro Arias-Vasquez; Edmund Sonuga-Barke; Philip J Asherson; Claiton H. D. Bau; Jan K Buitelaar; Bru Cormand; Stephen V Faraone; Jan Haavik; Stefan E Johansson; Jonna Kuntsi; Henrik Larsson; Klaus Peter Lesch; Andreas Reif; Luis A. Rohde; Miquel Casas; Anders D. Borglum; Barbara Franke; Josep A Ramos-Quiroga; Maria Soler Artigas; Marta Ribases

doi:10.1038/s41386-020-0664-5

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Paula Rovira, Ditte Demontis, Cristina Sanchez-Mora, Tetyana Zayats, Marieke Klein, Nina Roth Mota, Heike Weber, Iris Garcia-Martinez, Miriea Pagerols, Laura Vilar-Ribo, Lorena Arribas, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Rosa Bosch, Gemma Espanol Martin, Peter Almos, Alysa E Doyle, Eugenio Horacio Grevet, Oliver GrimmAnne Halmoy, Martine Hoogman, Mara Hutz, Christian Jacob, Sarah Kittel-Schneider, Per M Knappskog, Astri Johansen Lundervold, Olga Rivero, Diego Luiz Rovaris, Angelica Salatino-Oliveira, Bruna Santos da Silva, Evgeniy Svirin, Emma Sprooten, Tatyana Strekalova, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), 23andMe Research Team, Alejandro Arias-Vasquez, Edmund Sonuga-Barke, Philip J Asherson, Claiton H. D. Bau, Jan K Buitelaar, Bru Cormand, Stephen V Faraone, Jan Haavik, Stefan E Johansson, Jonna Kuntsi, Henrik Larsson, Klaus Peter Lesch, Andreas Reif, Luis A. Rohde, Miquel Casas, Anders D. Borglum, Barbara Franke, Josep A Ramos-Quiroga, Maria Soler Artigas, Marta Ribases

Psychology

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

Original language	English
Pages (from-to)	1617-1626
Number of pages	10
Journal	Neuropsychopharmacology
Volume	45
DOIs	https://doi.org/10.1038/s41386-020-0664-5
Publication status	Published - Sep 2020

Keywords

ADHD
genetic markers

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10.1038/s41386-020-0664-5

314575062-oaFinal published version, 22.3 MB

Cite this

Rovira, P., Demontis, D., Sanchez-Mora, C., Zayats, T., Klein, M., Roth Mota, N., Weber, H., Garcia-Martinez, I., Pagerols, M., Vilar-Ribo, L., Arribas, L., Richarte, V., Corrales, M., Fadeuilhe, C., Bosch, R., Espanol Martin, G., Almos, P., Doyle, A. E., Horacio Grevet, E., ... Ribases, M. (2020). Shared genetic background between children and adults with attention deficit/hyperactivity disorder. Neuropsychopharmacology, 45, 1617-1626. https://doi.org/10.1038/s41386-020-0664-5

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title = "Shared genetic background between children and adults with attention deficit/hyperactivity disorder",

abstract = "Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective. ",

keywords = "ADHD, genetic markers",

author = "Paula Rovira and Ditte Demontis and Cristina Sanchez-Mora and Tetyana Zayats and Marieke Klein and {Roth Mota}, Nina and Heike Weber and Iris Garcia-Martinez and Miriea Pagerols and Laura Vilar-Ribo and Lorena Arribas and Vanesa Richarte and Montserrat Corrales and Christian Fadeuilhe and Rosa Bosch and {Espanol Martin}, Gemma and Peter Almos and Doyle, {Alysa E} and {Horacio Grevet}, Eugenio and Oliver Grimm and Anne Halmoy and Martine Hoogman and Mara Hutz and Christian Jacob and Sarah Kittel-Schneider and Knappskog, {Per M} and Lundervold, {Astri Johansen} and Olga Rivero and {Luiz Rovaris}, Diego and Angelica Salatino-Oliveira and {Santos da Silva}, Bruna and Evgeniy Svirin and Emma Sprooten and Tatyana Strekalova and {ADHD Working Group of the Psychiatric Genomics Consortium (PGC)} and {23andMe Research Team} and Mark Bellgrove and Ziarih Hawi and Alejandro Arias-Vasquez and Edmund Sonuga-Barke and Asherson, {Philip J} and Bau, {Claiton H. D.} and Buitelaar, {Jan K} and Bru Cormand and Faraone, {Stephen V} and Jan Haavik and Johansson, {Stefan E} and Jonna Kuntsi and Henrik Larsson and Lesch, {Klaus Peter} and Andreas Reif and Rohde, {Luis A.} and Miquel Casas and Borglum, {Anders D.} and Barbara Franke and Ramos-Quiroga, {Josep A} and {Soler Artigas}, Maria and Marta Ribases",

year = "2020",

month = sep,

doi = "10.1038/s41386-020-0664-5",

language = "English",

volume = "45",

pages = "1617--1626",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Nature Publishing Group",

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Rovira, P, Demontis, D, Sanchez-Mora, C, Zayats, T, Klein, M, Roth Mota, N, Weber, H, Garcia-Martinez, I, Pagerols, M, Vilar-Ribo, L, Arribas, L, Richarte, V, Corrales, M, Fadeuilhe, C, Bosch, R, Espanol Martin, G, Almos, P, Doyle, AE, Horacio Grevet, E, Grimm, O, Halmoy, A, Hoogman, M, Hutz, M, Jacob, C, Kittel-Schneider, S, Knappskog, PM, Lundervold, AJ, Rivero, O, Luiz Rovaris, D, Salatino-Oliveira, A, Santos da Silva, B, Svirin, E, Sprooten, E, Strekalova, T, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), 23andMe Research Team, Arias-Vasquez, A, Sonuga-Barke, E, Asherson, PJ, Bau, CHD, Buitelaar, JK, Cormand, B, Faraone, SV, Haavik, J, Johansson, SE, Kuntsi, J, Larsson, H, Lesch, KP, Reif, A, Rohde, LA, Casas, M, Borglum, AD, Franke, B, Ramos-Quiroga, JA, Soler Artigas, M & Ribases, M 2020, 'Shared genetic background between children and adults with attention deficit/hyperactivity disorder', Neuropsychopharmacology, vol. 45, pp. 1617-1626. https://doi.org/10.1038/s41386-020-0664-5

TY - JOUR

T1 - Shared genetic background between children and adults with attention deficit/hyperactivity disorder

AU - Rovira, Paula

AU - Demontis, Ditte

AU - Sanchez-Mora, Cristina

AU - Zayats, Tetyana

AU - Klein, Marieke

AU - Roth Mota, Nina

AU - Weber, Heike

AU - Garcia-Martinez, Iris

AU - Pagerols, Miriea

AU - Vilar-Ribo, Laura

AU - Arribas, Lorena

AU - Richarte, Vanesa

AU - Corrales, Montserrat

AU - Fadeuilhe, Christian

AU - Bosch, Rosa

AU - Espanol Martin, Gemma

AU - Almos, Peter

AU - Doyle, Alysa E

AU - Horacio Grevet, Eugenio

AU - Grimm, Oliver

AU - Halmoy, Anne

AU - Hoogman, Martine

AU - Hutz, Mara

AU - Jacob, Christian

AU - Kittel-Schneider, Sarah

AU - Knappskog, Per M

AU - Lundervold, Astri Johansen

AU - Rivero, Olga

AU - Luiz Rovaris, Diego

AU - Salatino-Oliveira, Angelica

AU - Santos da Silva, Bruna

AU - Svirin, Evgeniy

AU - Sprooten, Emma

AU - Strekalova, Tatyana

AU - ADHD Working Group of the Psychiatric Genomics Consortium (PGC)

AU - 23andMe Research Team

AU - Bellgrove, Mark

AU - Hawi, Ziarih

AU - Arias-Vasquez, Alejandro

AU - Sonuga-Barke, Edmund

AU - Asherson, Philip J

AU - Bau, Claiton H. D.

AU - Buitelaar, Jan K

AU - Cormand, Bru

AU - Faraone, Stephen V

AU - Haavik, Jan

AU - Johansson, Stefan E

AU - Kuntsi, Jonna

AU - Larsson, Henrik

AU - Lesch, Klaus Peter

AU - Reif, Andreas

AU - Rohde, Luis A.

AU - Casas, Miquel

AU - Borglum, Anders D.

AU - Franke, Barbara

AU - Ramos-Quiroga, Josep A

AU - Soler Artigas, Maria

AU - Ribases, Marta

PY - 2020/9

Y1 - 2020/9

N2 - Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

AB - Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

KW - ADHD

KW - genetic markers

U2 - 10.1038/s41386-020-0664-5

DO - 10.1038/s41386-020-0664-5

M3 - Article

C2 - 32279069

VL - 45

SP - 1617

EP - 1626

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

ER -