Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Nadia R Cohen; Patrick J Brennan; Tal Shay; Gerald F Watts; Manfred Brigl; Joonsoo Kang; Michael B Brenner; Paul Monach; Susan A Shinton; Richard R Hardy; Radu Jianu; David Koller; Jim J Collins; Roi Gazit; Brian S Garrison; Derrick J Rossi; Kavitha Narayan; Katelyn Sylvia; Anne Fletcher; Kutlu G Elpek; Angelique Bellemare-Pelletier; Deepali Malhotra; Shannon J Turley; J Adam Best; Jamie Knell; Ananda W Goldrath; Vladimir Jojic; Daphne Koller; Aviv Regev; Taras Kreslavsky; Natalie A Bezman; Joseph C Sun; Charlie C Kim; Lewis L Lanier; Jennifer C Miller; Brian D Brown; Miriam Merad; Emmanuel L Gautier; Claudia V Jakubzick; Gwendalyn L Randolph; Francis S Kim; Tata N Rao; Amy Wagers; Tracy S P Heng; Michio W Painter; Jeffrey A Ericson; Scott P Davis; Ayla Ergun; Michael Mingueneau; Diane Mathis; Christophe Benoist

doi:10.1038/ni.2490

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Nadia R Cohen, Patrick J Brennan, Tal Shay, Gerald F Watts, Manfred Brigl, Joonsoo Kang, Michael B Brenner, Paul Monach, Susan A Shinton, Richard R Hardy, Radu Jianu, David Koller, Jim J Collins, Roi Gazit, Brian S Garrison, Derrick J Rossi, Kavitha Narayan, Katelyn Sylvia, Anne Fletcher, Kutlu G ElpekAngelique Bellemare-Pelletier, Deepali Malhotra, Shannon J Turley, J Adam Best, Jamie Knell, Ananda W Goldrath, Vladimir Jojic, Daphne Koller, Aviv Regev, Taras Kreslavsky, Natalie A Bezman, Joseph C Sun, Charlie C Kim, Lewis L Lanier, Jennifer C Miller, Brian D Brown, Miriam Merad, Emmanuel L Gautier, Claudia V Jakubzick, Gwendalyn L Randolph, Francis S Kim, Tata N Rao, Amy Wagers, Tracy S P Heng, Michio W Painter, Jeffrey A Ericson, Scott P Davis, Ayla Ergun, Michael Mingueneau, Diane Mathis, Christophe Benoist

Research output: Contribution to journal › Article › Research › peer-review

105 Citations (Scopus)

Abstract

Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in gammadelta T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.

Original language	English
Pages (from-to)	90-99
Number of pages	10
Journal	Nature Immunology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/ni.2490
Publication status	Published - 2013
Externally published	Yes

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Cohen, N. R., Brennan, P. J., Shay, T., Watts, G. F., Brigl, M., Kang, J., Brenner, M. B., Monach, P., Shinton, S. A., Hardy, R. R., Jianu, R., Koller, D., Collins, J. J., Gazit, R., Garrison, B. S., Rossi, D. J., Narayan, K., Sylvia, K., Fletcher, A., ... Benoist, C. (2013). Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nature Immunology, 14(1), 90-99. https://doi.org/10.1038/ni.2490

@article{e2fc6fc704794610afebda4c70006d64,

title = "Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells",

abstract = "Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in gammadelta T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.",

author = "Cohen, {Nadia R} and Brennan, {Patrick J} and Tal Shay and Watts, {Gerald F} and Manfred Brigl and Joonsoo Kang and Brenner, {Michael B} and Paul Monach and Shinton, {Susan A} and Hardy, {Richard R} and Radu Jianu and David Koller and Collins, {Jim J} and Roi Gazit and Garrison, {Brian S} and Rossi, {Derrick J} and Kavitha Narayan and Katelyn Sylvia and Anne Fletcher and Elpek, {Kutlu G} and Angelique Bellemare-Pelletier and Deepali Malhotra and Turley, {Shannon J} and Best, {J Adam} and Jamie Knell and Goldrath, {Ananda W} and Vladimir Jojic and Daphne Koller and Aviv Regev and Taras Kreslavsky and Bezman, {Natalie A} and Sun, {Joseph C} and Kim, {Charlie C} and Lanier, {Lewis L} and Miller, {Jennifer C} and Brown, {Brian D} and Miriam Merad and Gautier, {Emmanuel L} and Jakubzick, {Claudia V} and Randolph, {Gwendalyn L} and Kim, {Francis S} and Rao, {Tata N} and Amy Wagers and Heng, {Tracy S P} and Painter, {Michio W} and Ericson, {Jeffrey A} and Davis, {Scott P} and Ayla Ergun and Michael Mingueneau and Diane Mathis and Christophe Benoist",

year = "2013",

doi = "10.1038/ni.2490",

language = "English",

volume = "14",

pages = "90--99",

journal = "Nature Immunology",

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Cohen, NR, Brennan, PJ, Shay, T, Watts, GF, Brigl, M, Kang, J, Brenner, MB, Monach, P, Shinton, SA, Hardy, RR, Jianu, R, Koller, D, Collins, JJ, Gazit, R, Garrison, BS, Rossi, DJ, Narayan, K, Sylvia, K, Fletcher, A, Elpek, KG, Bellemare-Pelletier, A, Malhotra, D, Turley, SJ, Best, JA, Knell, J, Goldrath, AW, Jojic, V, Koller, D, Regev, A, Kreslavsky, T, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Miller, JC, Brown, BD, Merad, M, Gautier, EL, Jakubzick, CV, Randolph, GL, Kim, FS, Rao, TN, Wagers, A, Heng, TSP, Painter, MW, Ericson, JA, Davis, SP, Ergun, A, Mingueneau, M, Mathis, D & Benoist, C 2013, 'Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells', Nature Immunology, vol. 14, no. 1, pp. 90-99. https://doi.org/10.1038/ni.2490

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AU - Cohen, Nadia R

AU - Brennan, Patrick J

AU - Shay, Tal

AU - Watts, Gerald F

AU - Brigl, Manfred

AU - Kang, Joonsoo

AU - Brenner, Michael B

AU - Monach, Paul

AU - Shinton, Susan A

AU - Hardy, Richard R

AU - Jianu, Radu

AU - Koller, David

AU - Collins, Jim J

AU - Gazit, Roi

AU - Garrison, Brian S

AU - Rossi, Derrick J

AU - Narayan, Kavitha

AU - Sylvia, Katelyn

AU - Fletcher, Anne

AU - Elpek, Kutlu G

AU - Bellemare-Pelletier, Angelique

AU - Malhotra, Deepali

AU - Turley, Shannon J

AU - Best, J Adam

AU - Knell, Jamie

AU - Goldrath, Ananda W

AU - Jojic, Vladimir

AU - Koller, Daphne

AU - Regev, Aviv

AU - Kreslavsky, Taras

AU - Bezman, Natalie A

AU - Sun, Joseph C

AU - Kim, Charlie C

AU - Lanier, Lewis L

AU - Miller, Jennifer C

AU - Brown, Brian D

AU - Merad, Miriam

AU - Gautier, Emmanuel L

AU - Jakubzick, Claudia V

AU - Randolph, Gwendalyn L

AU - Kim, Francis S

AU - Rao, Tata N

AU - Wagers, Amy

AU - Heng, Tracy S P

AU - Painter, Michio W

AU - Ericson, Jeffrey A

AU - Davis, Scott P

AU - Ergun, Ayla

AU - Mingueneau, Michael

AU - Mathis, Diane

AU - Benoist, Christophe

PY - 2013

Y1 - 2013

N2 - Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in gammadelta T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.

AB - Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in gammadelta T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23202270

U2 - 10.1038/ni.2490

DO - 10.1038/ni.2490

M3 - Article

SN - 1529-2908

VL - 14

SP - 90

EP - 99

JO - Nature Immunology

JF - Nature Immunology

IS - 1

ER -

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Abstract

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