Shaping the T-cell repertoire in the periphery

Stacey Allen, Stephen J. Turner, Dorothée Bourges, Paul A. Gleeson, Ian R. Van Driel

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self-reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T-cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T-cell differentiation.

Original languageEnglish
Pages (from-to)60-69
Number of pages10
JournalImmunology and Cell Biology
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Keywords

  • dendritic cells
  • immune response
  • immune tolerance
  • T cell
  • Treg cells

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